Seroatlas · Human Serome Atlas

CREB3

Cyclic AMP-responsive element-binding protein 3

Also known as: CREB3_HUMAN, Luman, LZIP, sLZIP

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O43889
Gene
CREB3
Ensembl
ENSG00000107175
Chromosome
9
Canonical length
371 aa
Protein class
Predicted membrane proteins, Transcription factors
Subcellular location
Vesicles,Plasma membrane,Primary cilium,Primary cilium tip,Primary cilium transition zone,Basal body,Cytosol
Quaternary structure
Homodimer

OverviewNCBI Gene

This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds to the cAMP-response element and regulates cell proliferation. The protein interacts with host cell factor C1, which also associates with the herpes simplex virus (HSV) protein VP16 that induces transcription of HSV immediate-early genes. This protein and VP16 both bind to the same site on host cell factor C1. It is thought that the interaction between this protein and host cell factor C1 plays a role in the establishment of latency during HSV infection. This protein also plays a role in leukocyte migration, tumor suppression, and endoplasmic reticulum stress-associated protein degradation. Additional transcript variants have been identified, but their biological validity has not been determined.[provided by RefSeq, Nov 2009]

Canonical amino-acid sequenceUniProt

371 residues, UniProt reviewed canonical sequence.

>O43889|CREB3
     1  MELELDAGDQ DLLAFLLEES GDLGTAPDEA VRAPLDWALP LSEVPSDWEV DDLLCSLLSP
    61  PASLNILSSS NPCLVHHDHT YSLPRETVSM DLESESCRKE GTQMTPQHME ELAEQEIARL
   121  VLTDEEKSLL EKEGLILPET LPLTKTEEQI LKRVRRKIRN KRSAQESRRK KKVYVGGLES
   181  RVLKYTAQNM ELQNKVQLLE EQNLSLLDQL RKLQAMVIEI SNKTSSSSTC ILVLLVSFCL
   241  LLVPAMYSSD TRGSLPAEHG VLSRQLRALP SEDPYQLELP ALQSEVPKDS THQWLDGSDC
   301  VLQAPGNTSC LLHYMPQAPS AEPPLEWPFP DLFSEPLCRG PILPLQANLT RKGGWLPTGS
   361  PSVILQDRYS G

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CREB3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.62
Highest tissue expression
51 nTPM

Expression across tissuesHPA

Tissue

  • adrenal gland: 51 nTPM
  • blood vessel: 48 nTPM
  • amygdala: 44 nTPM
  • cerebral cortex: 43 nTPM
  • testis: 43 nTPM
  • prostate: 43 nTPM

Single-cell type

  • late spermatids: 692 nCPM
  • early spermatids: 193 nCPM
  • late primary spermatocytes: 103 nCPM
  • enterocytes: 82 nCPM
  • epididymal principal cells: 79 nCPM
  • extravillous trophoblasts: 75 nCPM

Immune cell

  • myeloid DC: 38 nTPM
  • classical monocyte: 34 nTPM
  • intermediate monocyte: 33 nTPM
  • plasmacytoid DC: 31 nTPM
  • MAIT T-cell: 31 nTPM
  • memory CD8 T-cell: 30 nTPM

Brain region

  • pons: 36 nTPM
  • hypothalamus: 36 nTPM
  • midbrain: 36 nTPM
  • medulla oblongata: 36 nTPM
  • thalamus: 34 nTPM
  • basal ganglia: 33 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.01
gnomAD pLI
0
gnomAD missense Z
0.04
DepMap mean gene effect
-0.13
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CREB3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CREB3 as an antibody target. Whether an autoantibody or antibody against CREB3 could matter depends on whether native CREB3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CREB3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CREB3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CREB3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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