Seroatlas · Human Serome Atlas

PKP3

Plakophilin-3

Also known as: PKP3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9Y446
Gene: PKP3
Ensembl: ENSG00000184363
Chromosome: 11
Canonical length: 797 aa
Protein class: Plasma proteins, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cell Junctions

OverviewNCBI Gene

This gene encodes a member of the arm-repeat (armadillo) and plakophilin gene families. Plakophilin proteins contain numerous armadillo repeats, localize to cell desmosomes and nuclei, and participate in linking cadherins to intermediate filaments in the cytoskeleton. This protein may act in cellular desmosome-dependent adhesion and signaling pathways. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2014]

Canonical amino-acid sequenceUniProt

797 residues, UniProt reviewed canonical sequence.

>Q9Y446|PKP3
     1  MQDGNFLLSA LQPEAGVCSL ALPSDLQLDR RGAEGPEAER LRAARVQEQV RARLLQLGQQ
    61  PRHNGAAEPE PEAETARGTS RGQYHTLQAG FSSRSQGLSG DKTSGFRPIA KPAYSPASWS
   121  SRSAVDLSCS RRLSSAHNGG SAFGAAGYGG AQPTPPMPTR PVSFHERGGV GSRADYDTLS
   181  LRSLRLGPGG LDDRYSLVSE QLEPAATSTY RAFAYERQAS SSSSRAGGLD WPEATEVSPS
   241  RTIRAPAVRT LQRFQSSHRS RGVGGAVPGA VLEPVARAPS VRSLSLSLAD SGHLPDVHGF
   301  NSYGSHRTLQ RLSSGFDDID LPSAVKYLMA SDPNLQVLGA AYIQHKCYSD AAAKKQARSL
   361  QAVPRLVKLF NHANQEVQRH ATGAMRNLIY DNADNKLALV EENGIFELLR TLREQDDELR
   421  KNVTGILWNL SSSDHLKDRL ARDTLEQLTD LVLSPLSGAG GPPLIQQNAS EAEIFYNATG
   481  FLRNLSSASQ ATRQKMRECH GLVDALVTSI NHALDAGKCE DKSVENAVCV LRNLSYRLYD
   541  EMPPSALQRL EGRGRRDLAG APPGEVVGCF TPQSRRLREL PLAADALTFA EVSKDPKGLE
   601  WLWSPQIVGL YNRLLQRCEL NRHTTEAAAG ALQNITAGDR RWAGVLSRLA LEQERILNPL
   661  LDRVRTADHH QLRSLTGLIR NLSRNARNKD EMSTKVVSHL IEKLPGSVGE KSPPAEVLVN
   721  IIAVLNNLVV ASPIAARDLL YFDGLRKLIF IKKKRDSPDS EKSSRAASSL LANLWQYNKL
   781  HRDFRAKGYR KEDFLGP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PKP3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.42
Highest tissue expression: 284 nTPM

Expression across tissuesHPA

Tissue

esophagus: 284 nTPM
skin: 213 nTPM
vagina: 99 nTPM
cervix: 83 nTPM
salivary gland: 49 nTPM
colon: 32 nTPM

Single-cell type

esophageal apical cells: 1,282 nCPM
esophageal suprabasal cells: 737 nCPM
esophageal basal cells: 314 nCPM
suprabasal keratinocytes: 290 nCPM
colonocytes: 249 nCPM
extravillous trophoblasts: 239 nCPM

Immune cell

NK-cell: 0.4 nTPM
MAIT T-cell: 0.2 nTPM
memory CD8 T-cell: 0.1 nTPM
naive CD8 T-cell: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM

Brain region

pons: 1.4 nTPM
cerebral cortex: 1.3 nTPM
medulla oblongata: 0.9 nTPM
hypothalamus: 0.8 nTPM
basal ganglia: 0.7 nTPM
spinal cord: 0.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.68
gnomAD pLI: 0
gnomAD missense Z: -0.73
DepMap mean gene effect: 0.09
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PKP3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PKP3 as an antibody target. Whether an autoantibody or antibody against PKP3 could matter depends on whether native PKP3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PKP3 is annotated at the cell surface, where native PKP3 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label PKP3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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