Seroatlas · Human Serome Atlas

ERRFI1

ERBB receptor feedback inhibitor 1

Also known as: ERRFI_HUMAN, GENE-33, MIG-6, RALT

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9UJM3
Gene
ERRFI1
Ensembl
ENSG00000116285
Chromosome
1
Canonical length
462 aa
Protein class
Predicted intracellular proteins
Subcellular location
Cytosol

OverviewNCBI Gene

ERRFI1 is a cytoplasmic protein whose expression is upregulated with cell growth (Wick et al., 1995 [PubMed 7641805]). It shares significant homology with the protein product of rat gene-33, which is induced during cell stress and mediates cell signaling (Makkinje et al., 2000 [PubMed 10749885]; Fiorentino et al., 2000 [PubMed 11003669]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

462 residues, UniProt reviewed canonical sequence.

>Q9UJM3|ERRFI1
     1  MSIAGVAAQE IRVPLKTGFL HNGRAMGNMR KTYWSSRSEF KNNFLNIDPI TMAYSLNSSA
    61  QERLIPLGHA SKSAPMNGHC FAENGPSQKS SLPPLLIPPS ENLGPHEEDQ VVCGFKKLTV
   121  NGVCASTPPL TPIKNSPSLF PCAPLCERGS RPLPPLPISE ALSLDDTDCE VEFLTSSDTD
   181  FLLEDSTLSD FKYDVPGRRS FRGCGQINYA YFDTPAVSAA DLSYVSDQNG GVPDPNPPPP
   241  QTHRRLRRSH SGPAGSFNKP AIRISNCCIH RASPNSDEDK PEVPPRVPIP PRPVKPDYRR
   301  WSAEVTSSTY SDEDRPPKVP PREPLSPSNS RTPSPKSLPS YLNGVMPPTQ SFAPDPKYVS
   361  SKALQRQNSE GSASKVPCIL PIIENGKKVS STHYYLLPER PPYLDKYEKF FREAEETNGG
   421  AQIQPLPADC GISSATEKPD SKTKMDLGGH VKRKHLSYVV SP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ERRFI1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.7
Highest tissue expression
695 nTPM

Expression across tissuesHPA

Tissue

  • liver: 695 nTPM
  • pancreas: 640 nTPM
  • blood vessel: 234 nTPM
  • skeletal muscle: 212 nTPM
  • kidney: 147 nTPM
  • ovary: 142 nTPM

Single-cell type

  • hepatocytes: 1,316 nCPM
  • basal keratinocytes: 1,275 nCPM
  • thymic myoid cells: 986 nCPM
  • proximal tubule cells: 984 nCPM
  • epididymal basal cells: 806 nCPM
  • alveolar cells type 2: 800 nCPM

Immune cell

  • non-classical monocyte: 2 nTPM
  • gdT-cell: 0.4 nTPM
  • memory CD4 T-cell: 0.4 nTPM
  • memory CD8 T-cell: 0.4 nTPM
  • naive CD8 T-cell: 0.4 nTPM
  • naive CD4 T-cell: 0.3 nTPM

Brain region

  • choroid plexus: 84 nTPM
  • cerebellum: 65 nTPM
  • medulla oblongata: 65 nTPM
  • spinal cord: 57 nTPM
  • white matter: 41 nTPM
  • hypothalamus: 39 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.88
gnomAD pLI
0.01
gnomAD missense Z
0.9
DepMap mean gene effect
0.15
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ERRFI1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ERRFI1 as an antibody target. Whether an autoantibody or antibody against ERRFI1 could matter depends on whether native ERRFI1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ERRFI1 is annotated at the cell surface, where native ERRFI1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label ERRFI1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ERRFI1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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