Seroatlas · Human Serome Atlas

TTC33

Tetratricopeptide repeat protein 33

Also known as: OSRF, TTC33_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6PID6
Gene: TTC33
Ensembl: ENSG00000113638
Chromosome: 5
Canonical length: 262 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Nucleoplasm,Golgi apparatus,Vesicles

OverviewNCBI Gene

No narrative summary is available for TTC33 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

262 residues, UniProt reviewed canonical sequence.

>Q6PID6|TTC33
     1  MASFGWKRKI GEKVSKVTSQ QFEAEAADEK DVVDNDEGNW LHAIKRRKEI LLEGCAEKSK
    61  QLKDEGASLA ENKRYREAIQ KWDEALQLTP NDATLYEMKS QVLMSLHEMF PAVHAAEMAV
   121  QQNPHSWESW QTLGRAQLGL GEIILAIRSF QVALHIYPMN PEIWKEDLSW ARTLQEQQKV
   181  AQRIKKSEAP AEVTHFSPKS IPDYDFESDE IVAVCAAIAE KEKTVSANKT MVIVSASGAI
   241  ETVTEKEDGA TPPDGSVFIK AR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TTC33 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.44
Highest tissue expression: 14 nTPM

Expression across tissuesHPA

Tissue

tongue: 14 nTPM
cerebellum: 13 nTPM
skeletal muscle: 13 nTPM
cerebral cortex: 11 nTPM
retina: 11 nTPM
basal ganglia: 8.6 nTPM

Single-cell type

platelets: 133 nCPM
t-cells: 109 nCPM
hematopoietic stem cells: 91 nCPM
innate lymphoid cells: 79 nCPM
fibro-adipogenic progenitors: 78 nCPM
cdc: 68 nCPM

Immune cell

basophil: 7.1 nTPM
non-classical monocyte: 6.6 nTPM
intermediate monocyte: 4.4 nTPM
eosinophil: 3.2 nTPM
naive CD4 T-cell: 2.5 nTPM
neutrophil: 2.5 nTPM

Brain region

cerebellum: 19 nTPM
cerebral cortex: 17 nTPM
hypothalamus: 14 nTPM
basal ganglia: 13 nTPM
white matter: 13 nTPM
midbrain: 12 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.03
gnomAD pLI: 0
gnomAD missense Z: 0.15
DepMap mean gene effect: -0.05
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 9% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

Tetratricopeptide-like helical domain superfamily
Tetratricopeptide repeat
Tetratricopeptide repeat-containing protein

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TTC33 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TTC33 as an antibody target. Whether an autoantibody or antibody against TTC33 could matter depends on whether native TTC33 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TTC33 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TTC33 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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