Seroatlas · Human Serome Atlas

CCDC97

Coiled-coil domain-containing protein 97

Also known as: CCD97_HUMAN, FLJ40267, MGC20255

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96F63
Gene: CCDC97
Ensembl: ENSG00000142039
Chromosome: 19
Canonical length: 343 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Plasma membrane,Cytosol

OverviewNCBI Gene

Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

343 residues, UniProt reviewed canonical sequence.

>Q96F63|CCDC97
     1  MEAVATATAA KEPDKGCIEP GPGHWGELSR TPVPSKPQDK VEAAEATPVA LDSDTSGAEN
    61  AAVSAMLHAV AASRLPVCSQ QQGEPDLTEH EKVAILAQLY HEKPLVFLER FRTGLREEHL
   121  ACFGHVRGDH RADFYCAEVA RQGTARPRTL RTRLRNRRYA ALRELIQGGE YFSDEQMRFR
   181  APLLYEQYIG QYLTQEELSA RTPTHQPPKP GSPGRPACPL SNLLLQSYEE RELQQRLLQQ
   241  QEEEEACLEE EEEEEDSDEE DQRSGKDSEA WVPDSEERLI LREEFTSRMH QRFLDGKDGD
   301  FDYSTVDDNP DFDNLDIVAR DEEERYFDEE EPEDAPSPEL DGD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CCDC97 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.46
Highest tissue expression: 30 nTPM

Expression across tissuesHPA

Tissue

testis: 30 nTPM
skeletal muscle: 29 nTPM
lymph node: 22 nTPM
epididymis: 22 nTPM
bone marrow: 22 nTPM
tonsil: 21 nTPM

Single-cell type

pdcs: 97 nCPM
t-cells: 84 nCPM
innate lymphoid cells: 82 nCPM
nk-cells: 79 nCPM
cdc: 60 nCPM
b-cells: 52 nCPM

Immune cell

MAIT T-cell: 14 nTPM
non-classical monocyte: 13 nTPM
gdT-cell: 12 nTPM
neutrophil: 12 nTPM
NK-cell: 10 nTPM
naive B-cell: 10 nTPM

Brain region

medulla oblongata: 49 nTPM
basal ganglia: 43 nTPM
thalamus: 42 nTPM
midbrain: 41 nTPM
pons: 41 nTPM
white matter: 41 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.47
gnomAD pLI: 0
gnomAD missense Z: 0.78
DepMap mean gene effect: -0.04
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

Ccdc97-like
CCD97-like, C-terminal
Coiled-coil domain containing protein 97-like, C-terminal

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CCDC97 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CCDC97 as an antibody target. Whether an autoantibody or antibody against CCDC97 could matter depends on whether native CCDC97 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CCDC97 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CCDC97 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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