Seroatlas · Human Serome Atlas

NUP37

Nucleoporin Nup37

Also known as: FLJ22618, MGC5585, NUP37_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8NFH4
Gene
NUP37
Ensembl
ENSG00000075188
Chromosome
12
Canonical length
326 aa
Protein class
Disease related genes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Transporters
Subcellular location
Nucleoplasm

OverviewNCBI Gene

Nuclear pore complexes (NPCs) are used for transporting macromolecules between the cytoplasm and the nucleus. NPCs consist of multiple copies of 30 distinct proteins (nucleoporins), which assemble into biochemically-separable subcomplexes. The protein encoded by this gene is part of a subcomplex (Nup107-160) that is required for proper NPC function as well as for normal kinetochore-microtubule interaction and mitosis. [provided by RefSeq, Dec 2015]

Canonical amino-acid sequenceUniProt

326 residues, UniProt reviewed canonical sequence.

>Q8NFH4|NUP37
     1  MKQDASRNAA YTVDCEDYVH VVEFNPFENG DSGNLIAYGG NNYVVIGTCT FQEEEADVEG
    61  IQYKTLRTFH HGVRVDGIAW SPETRLDSLP PVIKFCTSAA DMKIRLFTSD LQDKNEYKVL
   121  EGHTDFINGL VFDPKEGQEI ASVSDDHTCR IWNLEGVQTA HFVLHSPGMS VCWHPEETFK
   181  LMVAEKNGTI RFYDLLAQQA ILSLESEQVP LMSAHWCLKN TFKVGAVAGN DWLIWDITRS
   241  SYPQNKRPVH MDRACLFRWS TISENLFATT GYPGKMASQF QIHHLGHPQP ILMGSVAVGS
   301  GLSWHRTLPL CVIGGDHKLL FWVTEV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NUP37 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.22
Highest tissue expression
31 nTPM

Expression across tissuesHPA

Tissue

  • tonsil: 31 nTPM
  • lymph node: 26 nTPM
  • thymus: 24 nTPM
  • rectum: 22 nTPM
  • bone marrow: 21 nTPM
  • epididymis: 20 nTPM

Single-cell type

  • extravillous trophoblasts: 118 nCPM
  • migrating cytotrophoblasts: 108 nCPM
  • gastric progenitor cells: 92 nCPM
  • cytotrophoblasts: 85 nCPM
  • esophageal basal cells: 67 nCPM
  • erythrocyte progenitors: 66 nCPM

Immune cell

  • basophil: 68 nTPM
  • T-reg: 46 nTPM
  • memory B-cell: 31 nTPM
  • myeloid DC: 30 nTPM
  • intermediate monocyte: 29 nTPM
  • eosinophil: 28 nTPM

Brain region

  • cerebral cortex: 22 nTPM
  • white matter: 19 nTPM
  • cerebellum: 18 nTPM
  • hippocampal formation: 17 nTPM
  • hypothalamus: 16 nTPM
  • thalamus: 16 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about NUP37.

Disease | AllUniProt

Conditions NUP37 is implicated in, by any mechanism.

  • Microcephaly 24, primary, autosomal recessive (MCPH24) MIM:618179

Disease | GeneticClinVar

4 pathogenic / likely-pathogenic of 68 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Microcephaly 24, primary, autosomal recessive

Disease | ImmuneIEDB

Conditions an epitope on NUP37 was assayed in.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.93
gnomAD pLI
0
gnomAD missense Z
0.47
DepMap mean gene effect
-0.19
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of NUP37 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NUP37 as an antibody target. Whether an autoantibody or antibody against NUP37 could matter depends on whether native NUP37 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NUP37 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NUP37 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/NUP37. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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