Seroatlas · Human Serome Atlas

NUP85

Nuclear pore complex protein Nup85

Also known as: FLJ12549, NUP75, NUP85_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9BW27
Gene
NUP85
Ensembl
ENSG00000125450
Chromosome
17
Canonical length
656 aa
Protein class
Disease related genes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Transporters
Subcellular location
Nucleoplasm,Vesicles,Actin filaments,Basal body,Cytosol

OverviewNCBI Gene

This gene encodes a protein component of the Nup107-160 subunit of the nuclear pore complex. Nuclear pore complexes are embedded in the nuclear envelope and promote bidirectional transport of macromolecules between the cytoplasm and nucleus. The encoded protein can also bind to the C-terminus of chemokine (C-C motif) receptor 2 (CCR2) and promote chemotaxis of monocytes, thereby participating in the inflammatory response. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]

Canonical amino-acid sequenceUniProt

656 residues, UniProt reviewed canonical sequence.

>Q9BW27|NUP85
     1  MEELDGEPTV TLIPGVNSKK NQMYFDWGPG EMLVCETSFN KKEKSEMVPS CPFIYIIRKD
    61  VDVYSQILRK LFNESHGIFL GLQRIDEELT GKSRKSQLVR VSKNYRSVIR ACMEEMHQVA
   121  IAAKDPANGR QFSSQVSILS AMELIWNLCE ILFIEVAPAG PLLLHLLDWV RLHVCEVDSL
   181  SADVLGSENP SKHDSFWNLV TILVLQGRLD EARQMLSKEA DASPASAGIC RIMGDLMRTM
   241  PILSPGNTQT LTELELKWQH WHEECERYLQ DSTFATSPHL ESLLKIMLGD EAALLEQKEL
   301  LSNWYHFLVT RLLYSNPTVK PIDLHYYAQS SLDLFLGGES SPEPLDNILL AAFEFDIHQV
   361  IKECSIALSN WWFVAHLTDL LDHCKLLQSH NLYFGSNMRE FLLLEYASGL FAHPSLWQLG
   421  VDYFDYCPEL GRVSLELHIE RIPLNTEQKA LKVLRICEQR QMTEQVRSIC KILAMKAVRN
   481  NRLGSALSWS IRAKDAAFAT LVSDRFLRDY CERGCFSDLD LIDNLGPAMM LSDRLTFLGK
   541  YREFHRMYGE KRFADAASLL LSLMTSRIAP RSFWMTLLTD ALPLLEQKQV IFSAEQTYEL
   601  MRCLEDLTSR RPVHGESDTE QLQDDDIETT KVEMLRLSLA RNLARAIIRE GSLEGS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NUP85 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.3
Highest tissue expression
40 nTPM

Expression across tissuesHPA

Tissue

  • cerebellum: 40 nTPM
  • thymus: 31 nTPM
  • tonsil: 25 nTPM
  • lymph node: 25 nTPM
  • spleen: 24 nTPM
  • skin: 23 nTPM

Single-cell type

  • oocytes: 120 nCPM
  • erythrocyte progenitors: 71 nCPM
  • monocyte progenitors: 58 nCPM
  • myonuclei: 48 nCPM
  • differentiating spermatogonia: 46 nCPM
  • early primary spermatocytes: 41 nCPM

Immune cell

  • classical monocyte: 25 nTPM
  • MAIT T-cell: 23 nTPM
  • intermediate monocyte: 23 nTPM
  • plasmacytoid DC: 23 nTPM
  • eosinophil: 22 nTPM
  • naive B-cell: 22 nTPM

Brain region

  • cerebellum: 26 nTPM
  • white matter: 16 nTPM
  • cerebral cortex: 14 nTPM
  • medulla oblongata: 14 nTPM
  • pons: 14 nTPM
  • basal ganglia: 13 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about NUP85.

Disease | AllUniProt

Conditions NUP85 is implicated in, by any mechanism.

Disease | GeneticClinVar

4 pathogenic / likely-pathogenic of 239 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Nephrotic syndrome, type 17

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.14
gnomAD pLI
1
gnomAD missense Z
0.76
DepMap mean gene effect
-1.47
DepMap dependency class
pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 10% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Nucleoporin Nup85-like
  • Nup85 Nucleoporin

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of NUP85 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NUP85 as an antibody target. Whether an autoantibody or antibody against NUP85 could matter depends on whether native NUP85 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NUP85 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NUP85 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/NUP85. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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