Seroatlas · Human Serome Atlas

SEC31B

Protein transport protein Sec31B

Also known as: DKFZP434M183, SC31B_HUMAN, SEC31B-1, SEC31L2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NQW1
Gene: SEC31B
Ensembl: ENSG00000075826
Chromosome: 10
Canonical length: 1179 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Vesicles,Cytosol

OverviewNCBI Gene

This gene encodes a protein of unknown function. The protein has moderate similarity to rat VAP1 protein which is an endosomal membrane-associated protein, containing a putative Ca2+/calmodulin-dependent kinase II phosphorylation site. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

1179 residues, UniProt reviewed canonical sequence.

>Q9NQW1|SEC31B
     1  MKLKELERPA VQAWSPASQY PLYLATGTSA QQLDSSFSTN GTLEIFEVDF RDPSLDLKHR
    61  GVLSALSRFH KLVWGSFGSG LLESSGVIVG GGDNGMLILY NVTHILSSGK EPVIAQKQKH
   121  TGAVRALDLN PFQGNLLASG ASDSEIFIWD LNNLNVPMTL GSKSQQPPED IKALSWNRQA
   181  QHILSSAHPS GKAVVWDLRK NEPIIKVSDH SNRMHCSGLA WHPDIATQLV LCSEDDRLPV
   241  IQLWDLRFAS SPLKVLESHS RGILSVSWSQ ADAELLLTSA KDSQILCRNL GSSEVVYKLP
   301  TQSSWCFDVQ WCPRDPSVFS AASFNGWISL YSVMGRSWEV QHMRQADKIS SSFSKGQPLP
   361  PLQVPEQVAQ APLIPPLKKP PKWIRRPTGV SFAFGGKLVT FGLPSTPAHL VPQPCPRLVF
   421  ISQVTTESEF LMRSAELQEA LGSGNLLNYC QNKSQQALLQ SEKMLWQFLK VTLEQDSRMK
   481  FLKLLGYSKD ELQKKVATWL KSDVGLGESP QPKGNDLNSD RQQAFCSQAS KHTTKEASAS
   541  SAFFDELVPQ NMTPWEIPIT KDIDGLLSQA LLLGELGPAV ELCLKEERFA DAIILAQAGG
   601  TDLLKQTQER YLAKKKTKIS SLLACVVQKN WKDVVCTCSL KNWREALALL LTYSGTEKFP
   661  ELCDMLGTRM EQEGSRALTS EARLCYVCSG SVERLVECWA KCHQALSPMA LQDLMEKVMV
   721  LNRSLEQLRG PHGVSPGPAT TYRVTQYANL LAAQGSLATA MSFLPRDCAQ PPVQQLRDRL
   781  FHAQGSAVLG QQSPPFPFPR IVVGATLHSK ETSSYRLGSQ PSHQVPTPSP RPRVFTPQSS
   841  PAMPLAPSHP SPYQGPRTQN ISDYRAPGPQ AIQPLPLSPG VRPASSQPQL LGGQRVQVPN
   901  PVGFPGTWPL PGSPLPMACP GIMRPGSTSL PETPRLFPLL PLRPLGPGRM VSHTPAPPAS
   961  FPVPYLPGDP GAPCSSVLPT TGILTPHPGP QDSWKEAPAP RGNLQRNKLP ETFMPPAPIT
  1021  APVMSLTPEL QGILPSQPPV SSVSHAPPGV PGELSLQLQH LPPEKMERKE LPPEHQSLKS
  1081  SFEALLQRCS LSATDLKTKR KLEEAAQRLE YLYEKLCEGT LSPHVVAGLH EVARCVDAGS
  1141  FEQGLAVHAQ VAGCSSFSEV SSFMPILKAV LIIAHKLLV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SEC31B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.41
Highest tissue expression: 7.7 nTPM

Expression across tissuesHPA

Tissue

tongue: 7.7 nTPM
cerebellum: 7.3 nTPM
skeletal muscle: 5.6 nTPM
cerebral cortex: 3.4 nTPM
pituitary gland: 3.3 nTPM
thymus: 2.7 nTPM

Single-cell type

thyrotrophs: 37 nCPM
myonuclei: 35 nCPM
retinal amacrine cells: 33 nCPM
astrocytes: 33 nCPM
retinal horizontal cells: 32 nCPM
somatotrophs: 30 nCPM

Immune cell

MAIT T-cell: 0.3 nTPM
naive B-cell: 0.1 nTPM
naive CD8 T-cell: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM

Brain region

cerebral cortex: 6.1 nTPM
cerebellum: 5 nTPM
white matter: 4.8 nTPM
basal ganglia: 4.5 nTPM
medulla oblongata: 4.4 nTPM
amygdala: 4.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.05
gnomAD pLI: 0
gnomAD missense Z: 0.06
DepMap mean gene effect: -0.01
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

structural molecule activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SEC31B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SEC31B as an antibody target. Whether an autoantibody or antibody against SEC31B could matter depends on whether native SEC31B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SEC31B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SEC31B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...