Seroatlas · Human Serome Atlas

MIOS

GATOR2 complex protein MIOS

Also known as: FLJ20323, MIO, MIOS_HUMAN, Sea4, Yulink

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9NXC5
Gene
MIOS
Ensembl
ENSG00000164654
Chromosome
7
Canonical length
875 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Cytosol

OverviewNCBI Gene

Predicted to enable zinc ion binding activity. Involved in cellular response to amino acid starvation; positive regulation of TORC1 signaling; and protein-containing complex localization. Located in several cellular components, including cytosol; lysosomal membrane; and nucleoplasm. Part of GATOR2 complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

875 residues, UniProt reviewed canonical sequence.

>Q9NXC5|MIOS
     1  MSGTKPDILW APHHVDRFVV CDSELSLYHV ESTVNSELKA GSLRLSEDSA ATLLSINSDT
    61  PYMKCVAWYL NYDPECLLAV GQANGRVVLT SLGQDHNSKF KDLIGKEFVP KHARQCNTLA
   121  WNPLDSNWLA AGLDKHRADF SVLIWDICSK YTPDIVPMEK VKLSAGETET TLLVTKPLYE
   181  LGQNDACLSL CWLPRDQKLL LAGMHRNLAI FDLRNTSQKM FVNTKAVQGV TVDPYFHDRV
   241  ASFYEGQVAI WDLRKFEKPV LTLTEQPKPL TKVAWCPTRT GLLATLTRDS NIIRLYDMQH
   301  TPTPIGDETE PTIIERSVQP CDNYIASFAW HPTSQNRMIV VTPNRTMSDF TVFERISLAW
   361  SPITSLMWAC GRHLYECTEE ENDNSLEKDI ATKMRLRALS RYGLDTEQVW RNHILAGNED
   421  PQLKSLWYTL HFMKQYTEDM DQKSPGNKGS LVYAGIKSIV KSSLGMVESS RHNWSGLDKQ
   481  SDIQNLNEER ILALQLCGWI KKGTDVDVGP FLNSLVQEGE WERAAAVALF NLDIRRAIQI
   541  LNEGASSEKG DLNLNVVAMA LSGYTDEKNS LWREMCSTLR LQLNNPYLCV MFAFLTSETG
   601  SYDGVLYENK VAVRDRVAFA CKFLSDTQLN RYIEKLTNEM KEAGNLEGIL LTGLTKDGVD
   661  LMESYVDRTG DVQTASYCML QGSPLDVLKD ERVQYWIENY RNLLDAWRFW HKRAEFDIHR
   721  SKLDPSSKPL AQVFVSCNFC GKSISYSCSA VPHQGRGFSQ YGVSGSPTKS KVTSCPGCRK
   781  PLPRCALCLI NMGTPVSSCP GGTKSDEKVD LSKDKKLAQF NNWFTWCHNC RHGGHAGHML
   841  SWFRDHAECP VSACTCKCMQ LDTTGNLVPA ETVQP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MIOS can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.3
Highest tissue expression
82 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 82 nTPM
  • tongue: 48 nTPM
  • tonsil: 28 nTPM
  • parathyroid gland: 27 nTPM
  • choroid plexus: 23 nTPM
  • esophagus: 22 nTPM

Single-cell type

  • thymic myoid cells: 310 nCPM
  • prostatic glandular cells: 130 nCPM
  • esophageal apical cells: 107 nCPM
  • myonuclei: 104 nCPM
  • choroid plexus epithelial cells: 99 nCPM
  • microglia: 99 nCPM

Immune cell

  • memory B-cell: 10 nTPM
  • intermediate monocyte: 9.9 nTPM
  • naive B-cell: 8.9 nTPM
  • eosinophil: 8.8 nTPM
  • myeloid DC: 7.6 nTPM
  • naive CD4 T-cell: 6 nTPM

Brain region

  • choroid plexus: 65 nTPM
  • cerebellum: 34 nTPM
  • hypothalamus: 29 nTPM
  • cerebral cortex: 27 nTPM
  • white matter: 26 nTPM
  • midbrain: 25 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.7
gnomAD pLI
0
gnomAD missense Z
1.37
DepMap mean gene effect
-0.39
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 10% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MIOS in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MIOS as an antibody target. Whether an autoantibody or antibody against MIOS could matter depends on whether native MIOS is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MIOS is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MIOS as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/MIOS. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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