Seroatlas · Human Serome Atlas

NUP160

Nuclear pore complex protein Nup160

Also known as: FLJ22583, KIAA0197, NU160_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q12769
Gene: NUP160
Ensembl: ENSG00000030066
Chromosome: 11
Canonical length: 1436 aa
Protein class: Disease related genes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Transporters

OverviewNCBI Gene

A structural constituent of nuclear pore. Involved in mRNA export from nucleus and nephron development. Located in kinetochore and nuclear envelope. Part of nuclear pore outer ring. Implicated in nephrotic syndrome type 19. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1436 residues, UniProt reviewed canonical sequence.

>Q12769|NUP160
     1  MLHLSAAPPA PPPEVTATAR PCLCSVGRRG DGGKMAAAGA LERSFVELSG AERERPRHFR
    61  EFTVCSIGTA NAVAGAVKYS ESAGGFYYVE SGKLFSVTRN RFIHWKTSGD TLELMEESLD
   121  INLLNNAIRL KFQNCSVLPG GVYVSETQNR VIILMLTNQT VHRLLLPHPS RMYRSELVVD
   181  SQMQSIFTDI GKVDFTDPCN YQLIPAVPGI SPNSTASTAW LSSDGEALFA LPCASGGIFV
   241  LKLPPYDIPG MVSVVELKQS SVMQRLLTGW MPTAIRGDQS PSDRPLSLAV HCVEHDAFIF
   301  ALCQDHKLRM WSYKEQMCLM VADMLEYVPV KKDLRLTAGT GHKLRLAYSP TMGLYLGIYM
   361  HAPKRGQFCI FQLVSTESNR YSLDHISSLF TSQETLIDFA LTSTDIWALW HDAENQTVVK
   421  YINFEHNVAG QWNPVFMQPL PEEEIVIRDD QDPREMYLQS LFTPGQFTNE ALCKALQIFC
   481  RGTERNLDLS WSELKKEVTL AVENELQGSV TEYEFSQEEF RNLQQEFWCK FYACCLQYQE
   541  ALSHPLALHL NPHTNMVCLL KKGYLSFLIP SSLVDHLYLL PYENLLTEDE TTISDDVDIA
   601  RDVICLIKCL RLIEESVTVD MSVIMEMSCY NLQSPEKAAE QILEDMITID VENVMEDICS
   661  KLQEIRNPIH AIGLLIREMD YETEVEMEKG FNPAQPLNIR MNLTQLYGSN TAGYIVCRGV
   721  HKIASTRFLI CRDLLILQQL LMRLGDAVIW GTGQLFQAQQ DLLHRTAPLL LSYYLIKWGS
   781  ECLATDVPLD TLESNLQHLS VLELTDSGAL MANRFVSSPQ TIVELFFQEV ARKHIISHLF
   841  SQPKAPLSQT GLNWPEMITA ITSYLLQLLW PSNPGCLFLE CLMGNCQYVQ LQDYIQLLHP
   901  WCQVNVGSCR FMLGRCYLVT GEGQKALECF CQAASEVGKE EFLDRLIRSE DGEIVSTPRL
   961  QYYDKVLRLL DVIGLPELVI QLATSAITEA GDDWKSQATL RTCIFKHHLD LGHNSQAYEA
  1021  LTQIPDSSRQ LDCLRQLVVV LCERSQLQDL VEFPYVNLHN EVVGIIESRA RAVDLMTHNY
  1081  YELLYAFHIY RHNYRKAGTV MFEYGMRLGR EVRTLRGLEK QGNCYLAALN CLRLIRPEYA
  1141  WIVQPVSGAV YDRPGASPKR NHDGECTAAP TNRQIEILEL EDLEKECSLA RIRLTLAQHD
  1201  PSAVAVAGSS SAEEMVTLLV QAGLFDTAIS LCQTFKLPLT PVFEGLAFKC IKLQFGGEAA
  1261  QAEAWAWLAA NQLSSVITTK ESSATDEAWR LLSTYLERYK VQNNLYHHCV INKLLSHGVP
  1321  LPNWLINSYK KVDAAELLRL YLNYDLLEEA VDLVSEYVDA VLGKGHQYFG IEFPLSATAP
  1381  MVWLPYSSID QLLQALGENS ANSHNIALSQ KILDKLEDYQ QKVDKATRDL LYRRTL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NUP160 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.27
Highest tissue expression: 30 nTPM

Expression across tissuesHPA

Tissue

thymus: 30 nTPM
tonsil: 21 nTPM
bone marrow: 20 nTPM
placenta: 20 nTPM
lymph node: 20 nTPM
ovary: 18 nTPM

Single-cell type

renal collecting duct intercalated cells: 117 nCPM
choroid plexus epithelial cells: 101 nCPM
distal convoluted tubule cells: 95 nCPM
oligodendrocyte progenitor cells: 89 nCPM
loop of henle epithelial cells: 75 nCPM
oligodendrocytes: 75 nCPM

Immune cell

plasmacytoid DC: 17 nTPM
memory B-cell: 16 nTPM
naive CD4 T-cell: 16 nTPM
naive B-cell: 16 nTPM
MAIT T-cell: 14 nTPM
eosinophil: 14 nTPM

Brain region

cerebellum: 22 nTPM
white matter: 20 nTPM
choroid plexus: 20 nTPM
basal ganglia: 15 nTPM
medulla oblongata: 15 nTPM
midbrain: 15 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about NUP160.

Disease | AllUniProt

Conditions NUP160 is implicated in, by any mechanism.

Nephrotic syndrome 19 (NPHS19) MIM:618178

Disease | GeneticClinVar

8 pathogenic / likely-pathogenic of 473 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Nephrotic syndrome, type 19
NUP160-related disorder

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.42
gnomAD pLI: 0
gnomAD missense Z: 1.04
DepMap mean gene effect: -1.35
DepMap dependency class: pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

structural constituent of nuclear pore

Cellular components

Protein domainsUniProt · Pfam · InterPro

Nucleoporin Nup120/160
NUP160, middle TPR domain
NUP160, C-terminal TPR domain
NUP160, helical domain
Nucleoporin Nup120/160, beta-propeller domain
Nucleoporin Nup120/160, beta-propeller domain
Nucleoporin NUP160, helical domain
Nup160 C-terminal TPR
NUP160/120 middle TPR

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of NUP160 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NUP160 as an antibody target. Whether an autoantibody or antibody against NUP160 could matter depends on whether native NUP160 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NUP160 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NUP160 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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