Seroatlas · Human Serome Atlas

WDR24

GATOR2 complex protein WDR24

Also known as: C16orf21, DKFZp434F054, JFP7, WDR24_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96S15
Gene: WDR24
Ensembl: ENSG00000127580
Chromosome: 16
Canonical length: 790 aa
Protein class: Predicted intracellular proteins
Subcellular location: Vesicles,Cytosol

OverviewNCBI Gene

Enables ubiquitin protein ligase activity. Involved in several processes, including cellular response to amino acid starvation; positive regulation of TORC1 signaling; and protein K6-linked ubiquitination. Located in cytosol and lysosomal membrane. Part of GATOR2 complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

790 residues, UniProt reviewed canonical sequence.

>Q96S15|WDR24
     1  MEKMSRVTTA LGGSVLTGRT MHCHLDAPAN AISVCRDAAQ VVVAGRSIFK IYAIEEEQFV
    61  EKLNLRVGRK PSLNLSCADV VWHQMDENLL ATAATNGVVV TWNLGRPSRN KQDQLFTEHK
   121  RTVNKVCFHP TEAHVLLSGS QDGFMKCFDL RRKDSVSTFS GQSESVRDVQ FSIRDYFTFA
   181  STFENGNVQL WDIRRPDRCE RMFTAHNGPV FCCDWHPEDR GWLATGGRDK MVKVWDMTTH
   241  RAKEMHCVQT IASVARVKWR PECRHHLATC SMMVDHNIYV WDVRRPFVPA AMFEEHRDVT
   301  TGIAWRHPHD PSFLLSGSKD SSLCQHLFRD ASQPVERANP EGLCYGLFGD LAFAAKESLV
   361  AAESGRKPYT GDRRHPIFFK RKLDPAEPFA GLASSALSVF ETEPGGGGMR WFVDTAERYA
   421  LAGRPLAELC DHNAKVAREL GRNQVAQTWT MLRIIYCSPG LVPTANLNHS VGKGGSCGLP
   481  LMNSFNLKDM APGLGSETRL DRSKGDARSD TVLLDSSATL ITNEDNEETE GSDVPADYLL
   541  GDVEGEEDEL YLLDPEHAHP EDPECVLPQE AFPLRHEIVD TPPGPEHLQD KADSPHVSGS
   601  EADVASLAPV DSSFSLLSVS HALYDSRLPP DFFGVLVRDM LHFYAEQGDV QMAVSVLIVL
   661  GERVRKDIDE QTQEHWYTSY IDLLQRFRLW NVSNEVVKLS TSRAVSCLNQ ASTTLHVNCS
   721  HCKRPMSSRG WVCDRCHRCA SMCAVCHHVV KGLFVWCQGC SHGGHLQHIM KWLEGSSHCP
   781  AGCGHLCEYS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against WDR24 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.38
Highest tissue expression: 14 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 14 nTPM
testis: 14 nTPM
skeletal muscle: 11 nTPM
liver: 11 nTPM
cerebral cortex: 10 nTPM
pituitary gland: 9.1 nTPM

Single-cell type

late spermatids: 76 nCPM
gastric progenitor cells: 37 nCPM
late primary spermatocytes: 31 nCPM
retinal pigment epithelial cells: 17 nCPM
early primary spermatocytes: 15 nCPM
early spermatids: 15 nCPM

Immune cell

non-classical monocyte: 7.8 nTPM
gdT-cell: 6.7 nTPM
T-reg: 6.1 nTPM
MAIT T-cell: 5.4 nTPM
classical monocyte: 5.1 nTPM
myeloid DC: 5.1 nTPM

Brain region

cerebellum: 18 nTPM
cerebral cortex: 16 nTPM
medulla oblongata: 16 nTPM
midbrain: 16 nTPM
choroid plexus: 16 nTPM
thalamus: 16 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.68
gnomAD pLI: 0
gnomAD missense Z: 2.79
DepMap mean gene effect: -0.44
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

WD40 repeat
WD40/YVTN repeat-like-containing domain superfamily
WD40 repeat, conserved site
WD40-repeat-containing domain superfamily
WD domain, G-beta repeat
GATOR2 complex protein WDR24

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of WDR24 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads WDR24 as an antibody target. Whether an autoantibody or antibody against WDR24 could matter depends on whether native WDR24 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

WDR24 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label WDR24 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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