CLTB
Clathrin light chain B
Also known as: CLCB_HUMAN, Lcb
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- P09497
- Gene
- CLTB
- Ensembl
- ENSG00000175416
- Chromosome
- 5
- Canonical length
- 229 aa
- Protein class
- Plasma proteins, Predicted intracellular proteins, Transporters
- Subcellular location
- Vesicles,Plasma membrane,Cytosol
OverviewNCBI Gene
Clathrin is a large, soluble protein composed of heavy and light chains. It functions as the main structural component of the lattice-type cytoplasmic face of coated pits and vesicles which entrap specific macromolecules during receptor-mediated endocytosis. This gene encodes one of two clathrin light chain proteins which are believed to function as regulatory elements. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]
Canonical amino-acid sequenceUniProt
229 residues, UniProt reviewed canonical sequence.
>P09497|CLTB
1 MADDFGFFSS SESGAPEAAE EDPAAAFLAQ QESEIAGIEN DEGFGAPAGS HAAPAQPGPT
61 SGAGSEDMGT TVNGDVFQEA NGPADGYAAI AQADRLTQEP ESIRKWREEQ RKRLQELDAA
121 SKVTEQEWRE KAKKDLEEWN QRQSEQVEKN KINNRIADKA FYQQPDADII GYVASEEAFV
181 KESKEETPGT EWEKVAQLCD FNPKSSKQCK DVSRLRSVLM SLKQTPLSRLocalizationUniProt · AlphaFold · HPA
Whether an antibody against CLTB can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.56
- Highest tissue expression
- 494 nTPM
Expression across tissuesHPA
Tissue
- esophagus: 494 nTPM
- skin: 473 nTPM
- skeletal muscle: 335 nTPM
- heart muscle: 325 nTPM
- vagina: 311 nTPM
- cervix: 239 nTPM
Single-cell type
- esophageal apical cells: 4,480 nCPM
- esophageal suprabasal cells: 2,587 nCPM
- suprabasal keratinocytes: 994 nCPM
- esophageal basal cells: 953 nCPM
- extravillous trophoblasts: 908 nCPM
- colonocytes: 688 nCPM
Immune cell
- eosinophil: 62 nTPM
- neutrophil: 37 nTPM
- T-reg: 25 nTPM
- non-classical monocyte: 21 nTPM
- myeloid DC: 20 nTPM
- classical monocyte: 20 nTPM
Brain region
- cerebral cortex: 177 nTPM
- pons: 149 nTPM
- white matter: 132 nTPM
- medulla oblongata: 131 nTPM
- hypothalamus: 130 nTPM
- thalamus: 128 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.6
- gnomAD pLI
- 0.33
- gnomAD missense Z
- 1.02
- DepMap mean gene effect
- -0.08
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of CLTB in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads CLTB as an antibody target. Whether an autoantibody or antibody against CLTB could matter depends on whether native CLTB is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
CLTB is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label CLTB as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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