Seroatlas · Human Serome Atlas

WDR59

GATOR2 complex protein WDR59

Also known as: FLJ12270, WDR59_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6PJI9
Gene: WDR59
Ensembl: ENSG00000103091
Chromosome: 16
Canonical length: 974 aa
Protein class: Predicted intracellular proteins
Subcellular location: Vesicles,Cytosol

OverviewNCBI Gene

Predicted to enable signaling adaptor activity. Involved in cellular response to amino acid starvation and positive regulation of TORC1 signaling. Located in cytosol and lysosomal membrane. Part of GATOR2 complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

974 residues, UniProt reviewed canonical sequence.

>Q6PJI9|WDR59
     1  MAARWSSENV VVEFRDSQAT AMSVDCLGQH AVLSGRRFLY IVNLDAPFEG HRKISRQSKW
    61  DIGAVQWNPH DSFAHYFAAS SNQRVDLYKW KDGSGEVGTT LQGHTRVISD LDWAVFEPDL
   121  LVTSSVDTYI YIWDIKDTRK PTVALSAVAG ASQVKWNKKN ANCLATSHDG DVRIWDKRKP
   181  STAVEYLAAH LSKIHGLDWH PDSEHILATS SQDNSVKFWD YRQPRKYLNI LPCQVPVWKA
   241  RYTPFSNGLV TVMVPQLRRE NSLLLWNVFD LNTPVHTFVG HDDVVLEFQW RKQKEGSKDY
   301  QLVTWSRDQT LRMWRVDSQM QRLCANDILD GVDEFIESIS LLPEPEKTLH TEDTDHQHTA
   361  SHGEEEALKE DPPRNLLEER KSDQLGLPQT LQQEFSLINV QIRNVNVEMD AADRSCTVSV
   421  HCSNHRVKML VKFPAQYPNN AAPSFQFINP TTITSTMKAK LLKILKDTAL QKVKRGQSCL
   481  EPCLRQLVSC LESFVNQEDS ASSNPFALPN SVTPPLPTFA RVTTAYGSYQ DANIPFPRTS
   541  GARFCGAGYL VYFTRPMTMH RAVSPTEPTP RSLSALSAYH TGLIAPMKIR TEAPGNLRLY
   601  SGSPTRSEKE QVSISSFYYK ERKSRRWKSK REGSDSGNRQ IKAAGKVIIQ DIACLLPVHK
   661  SLGELYILNV NDIQETCQKN AASALLVGRK DLVQVWSLAT VATDLCLGPK SDPDLETPWA
   721  RHPFGRQLLE SLLAHYCRLR DVQTLAMLCS VFEAQSRPQG LPNPFGPFPN RSSNLVVSHS
   781  RYPSFTSSGS CSSMSDPGLN TGGWNIAGRE AEHLSSPWGE SSPEELRFGS LTYSDPRERE
   841  RDQHDKNKRL LDPANTQQFD DFKKCYGEIL YRWGLREKRA EVLKFVSCPP DPHKGIEFGV
   901  YCSHCRSEVR GTQCAICKGF TFQCAICHVA VRGSSNFCLT CGHGGHTSHM MEWFRTQEVC
   961  PTGCGCHCLL ESTF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against WDR59 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.38
Highest tissue expression: 35 nTPM

Expression across tissuesHPA

Tissue

retina: 35 nTPM
liver: 33 nTPM
skeletal muscle: 23 nTPM
thyroid gland: 22 nTPM
ovary: 22 nTPM
cerebellum: 21 nTPM

Single-cell type

retinal ganglion cells: 170 nCPM
proximal tubule cells: 166 nCPM
pancreatic islet cells: 150 nCPM
myonuclei: 146 nCPM
sertoli cells: 125 nCPM
adrenal cortex cells: 123 nCPM

Immune cell

MAIT T-cell: 3.4 nTPM
memory B-cell: 1.9 nTPM
memory CD4 T-cell: 1.9 nTPM
memory CD8 T-cell: 1.5 nTPM
naive CD8 T-cell: 1.4 nTPM
naive CD4 T-cell: 1.2 nTPM

Brain region

white matter: 57 nTPM
basal ganglia: 45 nTPM
cerebral cortex: 44 nTPM
thalamus: 43 nTPM
hypothalamus: 41 nTPM
medulla oblongata: 41 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.72
gnomAD pLI: 0
gnomAD missense Z: 1.25
DepMap mean gene effect: -0.32
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

WD40 repeat
RWD domain
WD40/YVTN repeat-like-containing domain superfamily
Ubiquitin-conjugating enzyme/RWD-like
WD40 repeat, conserved site
WD40-repeat-containing domain superfamily
WD domain, G-beta repeat
WDR59, modified RING finger, H2 subclass, C3H3C2-type
WDR59/RTC1-like, RING zinc finger domain
GATOR complex protein WDR59-like
RING/Ubox like zinc-binding domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of WDR59 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads WDR59 as an antibody target. Whether an autoantibody or antibody against WDR59 could matter depends on whether native WDR59 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

WDR59 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label WDR59 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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