Seroatlas · Human Serome Atlas

NUP107

Nuclear pore complex protein Nup107

Also known as: NU107_HUMAN, NUP84

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P57740
Gene: NUP107
Ensembl: ENSG00000111581
Chromosome: 12
Canonical length: 925 aa
Protein class: Disease related genes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Transporters
Subcellular location: Nucleoplasm,Nuclear membrane,Centrosome

OverviewNCBI Gene

This gene encodes a member of the nucleoporin family. The protein is localized to the nuclear rim and is an essential component of the nuclear pore complex (NPC). All molecules entering or leaving the nucleus either diffuse through or are actively transported by the NPC. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

925 residues, UniProt reviewed canonical sequence.

>P57740|NUP107
     1  MDRSGFGEIS SPVIREAEVT RTARKQSAQK RVLLQASQDE NFGNTTPRNQ VIPRTPSSFR
    61  QPFTPTSRSL LRQPDISCIL GTGGKSPRLT QSSGFFGNLS MVTNLDDSNW AAAFSSQRSG
   121  LFTNTEPHSI TEDVTISAVM LREDDPGEAA SMSMFSDFLQ SFLKHSSSTV FDLVEEYENI
   181  CGSQVNILSK IVSRATPGLQ KFSKTASMLW LLQQEMVTWR LLASLYRDRI QSALEEESVF
   241  AVTAVNASEK TVVEALFQRD SLVRQSQLVV DWLESIAKDE IGEFSDNIEF YAKSVYWENT
   301  LHTLKQRQLT SYVGSVRPLV TELDPDAPIR QKMPLDDLDR EDEVRLLKYL FTLIRAGMTE
   361  EAQRLCKRCG QAWRAATLEG WKLYHDPNVN GGTELEPVEG NPYRRIWKIS CWRMAEDELF
   421  NRYERAIYAA LSGNLKQLLP VCDTWEDTVW AYFRVMVDSL VEQEIQTSVA TLDETEELPR
   481  EYLGANWTLE KVFEELQATD KKRVLEENQE HYHIVQKFLI LGDIDGLMDE FSKWLSKSRN
   541  NLPGHLLRFM THLILFFRTL GLQTKEEVSI EVLKTYIQLL IREKHTNLIA FYTCHLPQDL
   601  AVAQYALFLE SVTEFEQRHH CLELAKEADL DVATITKTVV ENIRKKDNGE FSHHDLAPAL
   661  DTGTTEEDRL KIDVIDWLVF DPAQRAEALK QGNAIMRKFL ASKKHEAAKE VFVKIPQDSI
   721  AEIYNQCEEQ GMESPLPAED DNAIREHLCI RAYLEAHETF NEWFKHMNSV PQKPALIPQP
   781  TFTEKVAHEH KEKKYEMDFG IWKGHLDALT ADVKEKMYNV LLFVDGGWMV DVREDAKEDH
   841  ERTHQMVLLR KLCLPMLCFL LHTILHSTGQ YQECLQLADM VSSERHKLYL VFSKEELRKL
   901  LQKLRESSLM LLDQGLDPLG YEIQL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NUP107 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.34
Highest tissue expression: 24 nTPM

Expression across tissuesHPA

Tissue

lymph node: 24 nTPM
tonsil: 24 nTPM
thymus: 24 nTPM
bone marrow: 23 nTPM
testis: 20 nTPM
appendix: 17 nTPM

Single-cell type

early primary spermatocytes: 194 nCPM
sertoli cells: 150 nCPM
erythrocyte progenitors: 126 nCPM
leydig cells: 114 nCPM
granulosa cells: 103 nCPM
megakaryocyte progenitors: 99 nCPM

Immune cell

NK-cell: 31 nTPM
MAIT T-cell: 23 nTPM
non-classical monocyte: 23 nTPM
naive CD4 T-cell: 22 nTPM
T-reg: 20 nTPM
naive CD8 T-cell: 20 nTPM

Brain region

cerebellum: 15 nTPM
white matter: 13 nTPM
choroid plexus: 11 nTPM
basal ganglia: 11 nTPM
midbrain: 9.4 nTPM
thalamus: 9.4 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about NUP107.

Disease | AllUniProt

Conditions NUP107 is implicated in, by any mechanism.

Nephrotic syndrome 11 (NPHS11) MIM:616730
Ovarian dysgenesis 6 (ODG6) MIM:618078
Galloway-Mowat syndrome 7 (GAMOS7) MIM:618348

Disease | GeneticClinVar

26 pathogenic / likely-pathogenic of 420 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Nephrotic syndrome, type 11
NUP107-related disorder
Galloway-Mowat syndrome 7
Ovarian dysgenesis 6
Inborn genetic diseases

Disease | ImmuneIEDB

Conditions an epitope on NUP107 was assayed in.

berylliosis T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.57
gnomAD pLI: 0
gnomAD missense Z: 1.89
DepMap mean gene effect: -1.05
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

structural constituent of nuclear pore

Cellular components

Protein domainsUniProt · Pfam · InterPro

Nuclear pore protein 84/107
Nuclear pore protein 84 / 107

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of NUP107 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NUP107 as an antibody target. Whether an autoantibody or antibody against NUP107 could matter depends on whether native NUP107 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NUP107 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NUP107 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...