Seroatlas · Human Serome Atlas

TNRC18

Trinucleotide repeat-containing gene 18 protein

Also known as: CAGL79, KIAA1856, TNC18_HUMAN, TNRC18A

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O15417
Gene
TNRC18
Ensembl
ENSG00000182095
Chromosome
7
Canonical length
2968 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Nuclear membrane,Mitochondria,Cytosol

OverviewNCBI Gene

Predicted to enable chromatin binding activity. Located in cytosol; mitochondrion; and nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

2968 residues, UniProt reviewed canonical sequence.

>O15417|TNRC18
     1  MDGRDFGPQR SVHGPPPPLL SGLAMDSHRV GAATAGRLPA SGLPGPLPPG KYMAGLNLHP
    61  HPGEAFLGSF VASGMGPSAS SHGSPVPLPS DLSFRSPTPS NLPMVQLWAA HAHEGFSHLP
   121  SGLYPSYLHL NHLEPPSSGS PLLSQLGQPS IFDTQKGQGP GGDGFYLPTA GAPGSLHSHA
   181  PSARTPGGGH SSGAPAKGSS SRDGPAKERA GRGGEPPPLF GKKDPRARGE EASGPRGVVD
   241  LTQEARAEGR QDRGPPRLAE RLSPFLAESK TKNAALQPSV LTMCNGGAGD VGLPALVAEA
   301  GRGGAKEAAR QDEGARLLRR TETLLPGPRP CPSPLPPPPA PPKGPPAPPA ATPAGVYTVF
   361  REQGREHRVV APTFVPSVEA FDERPGPIQI ASQARDARAR EREAGRPGVL QAPPGSPRPL
   421  DRPEGLREKN SVIRSLKRPP PADAPTVRAT RASPDPRAYV PAKELLKPEA DPRPCERAPR
   481  GPAGPAAQQA AKLFGLEPGR PPPTGPEHKW KPFELGNFAA TQMAVLAAQH HHSRAEEEAA
   541  VVAASSSKKA YLDPGAVLPR SAATCGRPVA DMHSAAHGSG EASAMQSLIK YSGSFARDAV
   601  AVRPGGCGKK SPFGGLGTMK PEPAPTSAGA SRAQARLPHS GGPAAGGGRQ LKRDPERPES
   661  AKAFGREGSG AQGEAEVRHP PVGIAVAVAR QKDSGGSGRL GPGLVDQERS LSLSNVKGHG
   721  RADEDCVDDR ARHREERLLG ARLDRDQEKL LRESKELADL ARLHPTSCAP NGLNPNLMVT
   781  GGPALAGSGR WSADPAAHLA THPWLPRSGN ASMWLAGHPY GLGPPSLHQG MAPAFPPGLG
   841  GSLPSAYQFV RDPQSGQLVV IPSDHLPHFA ELMERATVPP LWPALYPPGR SPLHHAQQLQ
   901  LFSQQHFLRQ QEFLYLQQQA AQALELQRSA QLVQERLKAQ EHRAEMEEKG SKRGLEAAGK
   961  AGLATAGPGL LPRKPPGLAA GPAGTYGKAV SPPPSPRASP VAALKAKVIQ KLEDVSKPPA
  1021  YAYPATPSSH PTSPPPASPP PTPGITRKEE APENVVEKKD LELEKEAPSP FQALFSDIPP
  1081  RYPFQALPPH YGRPYPFLLQ PTAAADADGL APDVPLPADG PERLALSPED KPIRLSPSKI
  1141  TEPLREGPEE EPLAEREVKA EVEDMDEGPT ELPPLESPLP LPAAEAMATP SPAGGCGGGL
  1201  LEAQALSATG QSCAEPSECP DFVEGPEPRV DSPGRTEPCT AALDLGVQLT PETLVEAKEE
  1261  PVEVPVAVPV VEAVPEEGLA QVAPSESQPT LEMSDCDVPA GEGQCPSLEP QEAVPVLGST
  1321  CFLEEASSDQ FLPSLEDPLA GMNALAAAAE LPQARPLPSP GAAGAQALEK LEAAESLVLE
  1381  QSFLHGITLL SEIAELELER RSQEMGGAER ALVARPSLES LLAAGSHMLR EVLDGPVVDP
  1441  LKNLRLPREL KPNKKYSWMR KKEERMYAMK SSLEDMDALE LDFRMRLAEV QRQYKEKQRE
  1501  LVKLQRRRDS EDRREEPHRS LARRGPGRPR KRTHAPSALS PPRKRGKSGH SSGKLSSKSL
  1561  LTSDDYELGA GIRKRHKGSE EEHDALIGMG KARGRNQTWD EHEASSDFIS QLKIKKKKMA
  1621  SDQEQLASKL DKALSLTKQD KLKSPFKFSD SAGGKSKTSG GCGRYLTPYD SLLGKNRKAL
  1681  AKGLGLSLKS SREGKHKRAA KTRKMEVGFK ARGQPKSAHS PFASEVSSYS YNTDSEEDEE
  1741  FLKDEWPAQG PSSSKLTPSL LCSMVAKNSK AAGGPKLTKR GLAAPRTLKP KPATSRKQPF
  1801  CLLLREAEAR SSFSDSSEES FDQDESSEEE DEEEELEEED EASGGGYRLG ARERALSPGL
  1861  EESGLGLLAR FAASALPSPT VGPSLSVVQL EAKQKARKKE ERQSLLGTEF EYTDSESEVK
  1921  VRKRSPAGLL RPKKGLGEPG PSLAAPTPGA RGPDPSSPDK AKLAVEKGRK ARKLRGPKEP
  1981  GFEAGPEASD DDLWTRRRSE RIFLHDASAA APAPVSTAPA TKTSRCAKGG PLSPRKDAGR
  2041  AKDRKDPRKK KKGKEAGPGA GLPPPRAPAL PSEARAPHAS SLTAAKRSKA KAKGKEVKKE
  2101  NRGKGGAVSK LMESMAAEED FEPNQDSSFS EDEHLPRGGA VERPLTPAPR SCIIDKDELK
  2161  DGLRVLIPMD DKLLYAGHVQ TVHSPDIYRV VVEGERGNRP HIYCLEQLLQ EAIIDVRPAS
  2221  TRFLPQGTRI AAYWSQQYRC LYPGTVVRGL LDLEDDGDLI TVEFDDGDTG RIPLSHIRLL
  2281  PPDYKIQCAE PSPALLVPSA KRRSRKTSKD TGEGKDGGTA GSEEPGAKAR GRGRKPSAKA
  2341  KGDRAATLEE GNPTDEVPST PLALEPSSTP GSKKSPPEPV DKRAKAPKAR PAPPQPSPAP
  2401  PAFTSCPAPE PFAELPAPAT SLAPAPLITM PATRPKPKKA RAAEESGAKG PRRPGEEAEL
  2461  LVKLDHEGVT SPKSKKAKEA LLLREDPGAG GWQEPKSLLS LGSYPPAAGS SEPKAPWPKA
  2521  TDGDLAQEPG PGLTFEDSGN PKSPDKAQAE QDGAEESESS SSSSSGSSSS SSSSSSSGSE
  2581  TEGEEEGDKN GDGGCGTGGR NCSAASSRAA SPASSSSSSS SSSSSSSSSS SSSSSSSSSS
  2641  SSSSSSSSSS SSSSSSSSSS SSSSSSSSSS STTDEDSSCS SDDEAAPAPT AGPSAQAALP
  2701  TKATKQAGKA RPSAHSPGKK TPAPQPQAPP PQPTQPLQPK AQAGAKSRPK KREGVHLPTT
  2761  KELAKRQRLP SVENRPKIAA FLPARQLWKW FGKPTQRRGM KGKARKLFYK AIVRGKEMIR
  2821  IGDCAVFLSA GRPNLPYIGR IQSMWESWGN NMVVRVKWFY HPEETSPGKQ FHQGQHWDQK
  2881  SSRSLPAALR VSSQRKDFME RALYQSSHVD ENDVQTVSHK CLVVGLEQYE QMLKTKKYQD
  2941  SEGLYYLAGT YEPTTGMIFS TDGVPVLC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TNRC18 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0
Highest tissue expression
69 nTPM

Expression across tissuesHPA

Tissue

  • blood vessel: 69 nTPM
  • endometrium: 62 nTPM
  • colon: 60 nTPM
  • urinary bladder: 51 nTPM
  • bone marrow: 50 nTPM
  • fallopian tube: 50 nTPM

Single-cell type

  • hematopoietic stem cells: 379 nCPM
  • neutrophils: 338 nCPM
  • microglia: 272 nCPM
  • renal collecting duct principal cells: 253 nCPM
  • distal convoluted tubule cells: 249 nCPM
  • renal connecting tubule cells: 235 nCPM

Immune cell

  • neutrophil: 21 nTPM
  • basophil: 14 nTPM
  • plasmacytoid DC: 5.4 nTPM
  • classical monocyte: 3.7 nTPM
  • eosinophil: 3.6 nTPM
  • NK-cell: 3.2 nTPM

Brain region

  • cerebellum: 144 nTPM
  • cerebral cortex: 136 nTPM
  • amygdala: 131 nTPM
  • basal ganglia: 130 nTPM
  • hippocampal formation: 130 nTPM
  • thalamus: 110 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.29
gnomAD pLI
0.99
gnomAD missense Z
-0.26
DepMap mean gene effect
-0.03
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TNRC18 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TNRC18 as an antibody target. Whether an autoantibody or antibody against TNRC18 could matter depends on whether native TNRC18 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TNRC18 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TNRC18 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TNRC18. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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