SAP30BP
SAP30-binding protein
Also known as: HCNGP, HTRG, HTRP, S30BP_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q9UHR5
- Gene
- SAP30BP
- Ensembl
- ENSG00000161526
- Chromosome
- 17
- Canonical length
- 308 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Nucleoplasm
OverviewNCBI Gene
Predicted to be involved in regulation of DNA-templated transcription. Located in intermediate filament cytoskeleton and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
308 residues, UniProt reviewed canonical sequence.
>Q9UHR5|SAP30BP
1 MAGKKNVLSS LAVYAEDSEP ESDGEAGIEA VGSAAEEKGG LVSDAYGEDD FSRLGGDEDG
61 YEEEEDENSR QSEDDDSETE KPEADDPKDN TEAEKRDPQE LVASFSERVR NMSPDEIKIP
121 PEPPGRCSNH LQDKIQKLYE RKIKEGMDMN YIIQRKKEFR NPSIYEKLIQ FCAIDELGTN
181 YPKDMFDPHG WSEDSYYEAL AKAQKIEMDK LEKAKKERTK IEFVTGTKKG TTTNATSTTT
241 TTASTAVADA QKRKSKWDSA IPVTTIAQPT ILTTTATLPA VVTVTTSASG SKTTVISAVG
301 TIVKKAKQLocalizationUniProt · AlphaFold · HPA
Whether an antibody against SAP30BP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.64
- Highest tissue expression
- 59 nTPM
Expression across tissuesHPA
Tissue
- choroid plexus: 59 nTPM
- spinal cord: 30 nTPM
- midbrain: 27 nTPM
- hippocampal formation: 26 nTPM
- amygdala: 24 nTPM
- salivary gland: 24 nTPM
Single-cell type
- neutrophils: 317 nCPM
- esophageal apical cells: 244 nCPM
- urothelial cells: 154 nCPM
- syncytiotrophoblasts: 132 nCPM
- late spermatids: 128 nCPM
- esophageal suprabasal cells: 117 nCPM
Immune cell
- plasmacytoid DC: 32 nTPM
- NK-cell: 28 nTPM
- MAIT T-cell: 27 nTPM
- T-reg: 26 nTPM
- memory CD8 T-cell: 25 nTPM
- eosinophil: 25 nTPM
Brain region
- choroid plexus: 38 nTPM
- white matter: 34 nTPM
- medulla oblongata: 32 nTPM
- midbrain: 28 nTPM
- spinal cord: 26 nTPM
- basal ganglia: 25 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.79
- gnomAD pLI
- 0
- gnomAD missense Z
- 1.75
- DepMap mean gene effect
- -1.55
- DepMap dependency class
- pan
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 10% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Cellular components
Protein domainsUniProt · Pfam · InterPro
- SAP30-binding protein
- HCNGP-like protein
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of SAP30BP in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads SAP30BP as an antibody target. Whether an autoantibody or antibody against SAP30BP could matter depends on whether native SAP30BP is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
SAP30BP is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label SAP30BP as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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