Seroatlas · Human Serome Atlas

BAHCC1

BAH and coiled-coil domain-containing protein 1

Also known as: BAHC1_HUMAN, BAHD2, KIAA1447

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9P281
Gene: BAHCC1
Ensembl: ENSG00000266074
Chromosome: 17
Canonical length: 2639 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoli

OverviewNCBI Gene

Predicted to enable chromatin binding activity. Predicted to act upstream of or within chromatin organization; locomotory behavior; and neuron differentiation. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

2639 residues, UniProt reviewed canonical sequence.

>Q9P281|BAHCC1
     1  MDGRDFAPPP HLLSERGSLG HRSAAAAARL APAGPAAQPP AHFQPGKYFP SPLPMASHTA
    61  SSRLMGSSPA SSFMGSFLTS SLGSAASTHP SGPSSSPPEQ AYRGSHPTTS QIWFSHSHEA
   121  PGYPRFSGSL ASTFLPVSHL DHHGNSNVLY GQHRFYGTQK DNFYLRNLPP QPTLLPANHN
   181  FPSVARAAPA HPMGSCSRDR DRGEAGSLQK GPKDFDRFLV GKELGREKAG KAAEGKERPA
   241  AEEDGGKERH KLVLPVPADG HCREGGPAPR GACEGRPKHL TSCLLNTKVL NGEMGRAALA
   301  SCAGGMLGRP GTGVVTSGRC AKEAAGPPEP GPAFSECLER RQMLHHTASY AGPPPPLSTA
   361  AGSFPCLQLH GGPDGLCPLQ DKAPRDLKAS GPTFVPSVGH LADKGRPFQA AEACAVAGEG
   421  KDRHLEGTMA PDHAAPYGVS YAHLKAEGKG ERRPGGFEAA LNPRLKGLDY LSSAGPEASF
   481  PGLPKSGLDK SGYFELPTSS QDCARPGHQD PLGGKAPQAC CTLDKTVGKE APAGPPGAQK
   541  VARIRHQQHL MAAEVEQGGI GAEAKRKSLE LASLGYSGPH LPPWGVQAGQ GTAMAISEER
   601  KAGAYLDPFG SGLQQAALLP QELPAPPDEV SAMKNLLKYS SQALVVGQKA PLVGLGGLKA
   661  SCIQQEAKFL SSKGPGQSER PDCARSREHD TTHGDGEVRQ PPVGIAVALA RQKDTVSRSE
   721  AAYGTNTARQ GRAAPAFKGG GGPRSTHALD LEAEEERTRL CDDRLGLASR ELLLQDSKDR
   781  VEFARIHPPS SCPGDLAPHL MMQSGQLGGD PAPHTHPHPP WLPRTRSPSL WMGGHSYGLG
   841  HPALHQNLPP GFPASVAGPV PSVFPLPQDA PTQLVILPSE PTPHSAPHAL ADVMDQASLW
   901  PPMYGGRGPA SHMQHPGQLP VYSRPQLLRQ QELYALQQQR AAQFQRKPED QHLDLEEPAQ
   961  EKAPKSTHKP VALTPTAPGA PSPAAGPTKL PPCCHPPDPK PPASSPTPPP RPSAPCTLNV
  1021  CPASSPGPGS RVRSAEEKNG EGQQSTADII TSEPVARAHS VAHAGLEFLA SNDPSTSASQ
  1081  SFGITDLPPG YLRPMAGLGF SLPSDVHSSN LEDPETMQTT APGAQPEPTR TFLPGEPPPC
  1141  SPRSLEEPGL LSGAREATQD LAATPYPTER GPQGKAADPS PLEGLQELQC AALLEAGGPE
  1201  ATGQAHSTQG GAREERSREE GEQGPSSGAS SQVLEQRAGS PGALEDEGEQ PAPEEDELEE
  1261  DELGQQSMED SEEDCGGAPD NSHPPRALPG LDALVAATIN LGDLPSDSPP DPQPPAASGP
  1321  PSTVPLPHSS GIHGIALLSE LADLAIQRQR SERTVPEEEE DVLAFNLQHL ATLATAWSLV
  1381  EAAGLDSSTA PAQPPTANPC SGPRLTPRMQ ILQRKDTWTP KTKPVCPLKA AIDRLDTQEV
  1441  GMRVRLAELQ RRYKEKQREL ARLQRKHDHE RDESSRSPAR RGPGRPRKRK HSSSLPAPRP
  1501  TGPLPRSDGK KVKAVRTSLG LLCAELRGGS GGEPAKKRSK LERSVYAGLQ TASVEKAQCK
  1561  KSSCQGGLAP SVAHRVAQLK PKVKSKGLPT GLSSFQQKEA TPGGRIREKL SRAKSAKVSG
  1621  ATRHPQPKGH GSRETPRCPA QPSVAASQEA GSGYDSEDCE GLLGTEAPPR EAGLLLHTGA
  1681  SVAVLGPSPS SVVKMEANQK AKKKKERQGL LGACRLSSPE SEVKIKRRSV KAKVGTTLER
  1741  APGQRPPGAL GKKKAKGKAK GSLRAEPGAT PSRDALFNPS RAFACREEGS QLASERLKRA
  1801  TRKGTVLQPV LRRKNGALSI TLATRNAKAI LGKGRKLSKV KHKAGKQGKG RAVSRLLESF
  1861  AVEEDFEFDD NSSFSEEEED EEEEEEDSGP LSAEQSAALA RSCAIHKEDL RDGLPVLIPK
  1921  EDSLLYAGSV RTLQPPDIYS IVIEGERGNR QRIYSLEQLL QEAVLDVRPQ SSRYLPPGTR
  1981  VCAYWSQKSR CLYPGNVVRG ASGDEDEDLD SVVVEFDDGD TGHIAVSNVR LLPPDFKIQC
  2041  TEPSPALLVS SSCRRTKKVS SEAPPPSEAA TPSLSPKAQD GPEALKTPGK KSISKDKAGK
  2101  AELLTSGAKS PTGASDHFLG RRGSPLLSWS AVAQTKRKAV AAASKGPGVL QNLFQLNGSS
  2161  KKLRAREALF PVHSVATPIF GNGFRADSFS SLASSYAPFV GGTGPGLPRG AHKLLRAKKA
  2221  ERVEAEKGGR RRAGGEFLVK LDHEGVTSPK NKTCKALLMG DKDFSPKLGR PLPSPSYVHP
  2281  ALVGKDKKGR APIPPLPMGL ALRKYAGQAE FPLPYDSDCH SSFSDEDEDG PGLAAGVPSR
  2341  FLARLSVSSS SSGSSTSSSS GSVSTSSLCS SDNEDSSYSS DDEDPALLLQ TCLTHPVPTL
  2401  LAQPEALRSK GSGPHAHAQR CFLSRATVAG TGAGSGPSSS SKSKLKRKEA LSFSKAKELS
  2461  RRQRPPSVEN RPKISAFLPA RQLWKWSGNP TQRRGMKGKA RKLFYKAIVR GEETLRVGDC
  2521  AVFLSAGRPN LPYIGRIESM WESWGSNMVV KVKWFYHPEE TKLGKRQCDG KNALYQSCHE
  2581  DENDVQTISH KCQVVAREQY EQMARSRKCQ DRQDLYYLAG TYDPTTGRLV TADGVPILC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against BAHCC1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.63
Highest tissue expression: 24 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 24 nTPM
thyroid gland: 7.8 nTPM
blood vessel: 7.6 nTPM
ovary: 7.2 nTPM
fallopian tube: 6.7 nTPM
cerebral cortex: 6.4 nTPM

Single-cell type

thymocytes: 95 nCPM
retinal bipolar cells: 74 nCPM
retinal amacrine cells: 70 nCPM
retinal ganglion cells: 46 nCPM
differentiating spermatogonia: 45 nCPM
retinal horizontal cells: 44 nCPM

Immune cell

eosinophil: 0.2 nTPM
plasmacytoid DC: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

cerebellum: 27 nTPM
white matter: 26 nTPM
cerebral cortex: 25 nTPM
thalamus: 24 nTPM
basal ganglia: 22 nTPM
medulla oblongata: 20 nTPM

OntologyGO

Molecular functions

chromatin binding

Protein domainsUniProt · Pfam · InterPro

Bromo adjacent homology (BAH) domain
Bromo adjacent homology (BAH) domain superfamily
BAHCC1-like, Tudor domain
BAH domain-containing protein
TNRC18/BAHCC1-like, SH3 domain
BAH domain
BAHCC1-like, Tudor domain
TNRC18-like,(4.1.1) SH3
BAH and coiled-coil domain-containing protein 1, Tudor domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of BAHCC1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads BAHCC1 as an antibody target. Whether an autoantibody or antibody against BAHCC1 could matter depends on whether native BAHCC1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

BAHCC1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label BAHCC1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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