Seroatlas · Human Serome Atlas

SIN3B

Paired amphipathic helix protein Sin3b

Also known as: KIAA0700, SIN3B_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O75182
Gene: SIN3B
Ensembl: ENSG00000127511
Chromosome: 19
Canonical length: 1162 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Plasma membrane

OverviewNCBI Gene

Predicted to enable transcription corepressor activity. Predicted to be involved in cardiac muscle tissue development; negative regulation of transcription by RNA polymerase II; and skeletal muscle tissue development. Predicted to be located in nucleus. Predicted to be part of Sin3-type complex. Predicted to be active in chromatin. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1162 residues, UniProt reviewed canonical sequence.

>O75182|SIN3B
     1  MAHAGGGSGG SGAGGPAGRG LSGARWGRSG SAGHEKLPVH VEDALTYLDQ VKIRFGSDPA
    61  TYNGFLEIMK EFKSQSIDTP GVIRRVSQLF HEHPDLIVGF NAFLPLGYRI DIPKNGKLNI
   121  QSPLTSQENS HNHGDGAEDF KQQVPYKEDK PQVPLESDSV EFNNAISYVN KIKTRFLDHP
   181  EIYRSFLEIL HTYQKEQLNT RGRPFRGMSE EEVFTEVANL FRGQEDLLSE FGQFLPEAKR
   241  SLFTGNGPCE MHSVQKNEHD KTPEHSRKRS RPSLLRPVSA PAKKKMKLRG TKDLSIAAVG
   301  KYGTLQEFSF FDKVRRVLKS QEVYENFLRC IALFNQELVS GSELLQLVSP FLGKFPELFA
   361  QFKSFLGVKE LSFAPPMSDR SGDGISREID YASCKRIGSS YRALPKTYQQ PKCSGRTAIC
   421  KELDHWTLLQ GSWTDDYCMS KFKNTCWIPG YSAGVLNDTW VSFPSWSEDS TFVSSKKTPY
   481  EEQLHRCEDE RFELDVVLET NLATIRVLES VQKKLSRMAP EDQEKFRLDD SLGGTSEVIQ
   541  RRAIYRIYGD KAPEIIESLK KNPVTAVPVV LKRLKAKEEE WREAQQGFNK IWREQYEKAY
   601  LKSLDHQAVN FKQNDTKALR SKSLLNEIES VYDEHQEQHS EGRSAPSSEP HLIFVYEDRQ
   661  ILEDAAALIS YYVKRQPAIQ KEDQGTIHQL LHQFVPSLFF SQQLDLGASE ESADEDRDSP
   721  QGQTTDPSER KKPAPGPHSS PPEEKGAFGD APATEQPPLP PPAPHKPLDD VYSLFFANNN
   781  WYFFLRLHQT LCSRLLKIYR QAQKQLLEYR TEKEREKLLC EGRREKGSDP AMELRLKQPS
   841  EVELEEYYPA FLDMVRSLLE GSIDPTQYED TLREMFTIHA YVGFTMDKLV QNIARQLHHL
   901  VSDDVCLKVV ELYLNEKKRG AAGGNLSSRC VRAARETSYQ WKAERCMADE NCFKVMFLQR
   961  KGQVIMTIEL LDTEEAQTED PVEVQHLARY VEQYVGTEGA SSSPTEGFLL KPVFLQRNLK
  1021  KFRRRWQSEQ ARALRGEARS SWKRLVGVES ACDVDCRFKL STHKMVFIVN SEDYMYRRGT
  1081  LCRAKQVQPL VLLRHHQHFE EWHSRWLEDN VTVEAASLVQ DWLMGEEDED MVPCKTLCET
  1141  VHVHGLPVTR YRVQYSRRPA SP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SIN3B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.44
Highest tissue expression: 57 nTPM

Expression across tissuesHPA

Tissue

endometrium: 57 nTPM
cervix: 56 nTPM
ovary: 56 nTPM
fallopian tube: 52 nTPM
testis: 50 nTPM
cerebral cortex: 45 nTPM

Single-cell type

syncytiotrophoblasts: 227 nCPM
peritubular myoid cells: 112 nCPM
leydig cells: 106 nCPM
sertoli cells: 85 nCPM
pituicytes/fscs: 70 nCPM
distal convoluted tubule cells: 63 nCPM

Immune cell

classical monocyte: 4.2 nTPM
eosinophil: 4 nTPM
intermediate monocyte: 3.8 nTPM
memory B-cell: 3.5 nTPM
non-classical monocyte: 3.4 nTPM
naive B-cell: 2.7 nTPM

Brain region

cerebral cortex: 97 nTPM
hippocampal formation: 93 nTPM
basal ganglia: 93 nTPM
pons: 89 nTPM
hypothalamus: 82 nTPM
amygdala: 81 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about SIN3B.

Disease | GeneticClinVar

3 pathogenic / likely-pathogenic of 290 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

SIN3B-related neurodevelopmental disorder
Congenital ocular coloboma
Neurodevelopmental disorder

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.2
gnomAD pLI: 1
gnomAD missense Z: 3.87
DepMap mean gene effect: -0.05
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SIN3B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SIN3B as an antibody target. Whether an autoantibody or antibody against SIN3B could matter depends on whether native SIN3B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SIN3B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SIN3B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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