MRPL2

Protein identityUniProt · HPA

UniProt accession

Q5T653

Gene

MRPL2

Ensembl

ENSG00000112651

Chromosome

6

Canonical length

305 aa

Protein class

Predicted intracellular proteins, Ribosomal proteins

Subcellular location

Nucleoplasm,Mitochondria

OverviewNCBI Gene

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein that belongs to the EcoL2 ribosomal protein family. A pseudogene corresponding to this gene is found on chromosome 12q. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2014]

Canonical amino-acid sequenceUniProt

305 residues, UniProt reviewed canonical sequence.

>Q5T653|MRPL2
     1  MALCALTRAL RSLNLAPPTV AAPAPSLFPA AQMMNNGLLQ QPSALMLLPC RPVLTSVALN
    61  ANFVSWKSRT KYTITPVKMR KSGGRDHTGR IRVHGIGGGH KQRYRMIDFL RFRPEETKSG
   121  PFEEKVIQVR YDPCRSADIA LVAGGSRKRW IIATENMQAG DTILNSNHIG RMAVAAREGD
   181  AHPLGALPVG TLINNVESEP GRGAQYIRAA GTCGVLLRKV NGTAIIQLPS KRQMQVLETC
   241  VATVGRVSNV DHNKRVIGKA GRNRWLGKRP NSGRWHRKGG WAGRKIRPLP PMKSYVKLPS
   301  ASAQS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MRPL2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.43

Highest tissue expression

74 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about MRPL2.

Disease | ImmuneIEDB

Conditions an epitope on MRPL2 was assayed in.

• colonic benign neoplasm T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.15

gnomAD pLI

0

gnomAD missense Z

0.13

DepMap mean gene effect

-0.27

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• mitochondrial translation

Molecular functions

• RNA binding
• structural constituent of ribosome

Cellular components

• mitochondrial inner membrane
• mitochondrial large ribosomal subunit
• mitochondrion
• nucleoplasm

Protein domainsUniProt · Pfam · InterPro

• Large ribosomal subunit protein uL2
• Translation protein SH3-like domain superfamily
• Nucleic acid-binding, OB-fold
• Large ribosomal subunit protein uL2, domain 2
• Large ribosomal subunit protein uL2, RNA-binding domain
• Large ribosomal subunit protein uL2, C-terminal
• Ribosomal Proteins L2, RNA binding N-terminal domain
• Ribosomal Proteins L2, C-terminal domain

KeywordsUniProt

• Mitochondrion
• Ribonucleoprotein
• Ribosomal protein
• Transit peptide

InteractionsUniProt · HPA

Protein binding partners of MRPL2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• DDX28
• MRPL1
• MRPL13
• MRPL14
• MRPL16
• MRPL17
• MRPL18
• MRPL23
• MRPL24
• MRPL32
• MRPL37
• MRPL40
• MRPL50
• MRPL58
• MRPL9
• NGRN
• RPS15
• TRUB2