Seroatlas · Human Serome Atlas

RICTOR

Rapamycin-insensitive companion of mTOR

Also known as: AVO3, KIAA1999, MGC39830, PIA, RICTR_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q6R327
Gene
RICTOR
Ensembl
ENSG00000164327
Chromosome
5
Canonical length
1708 aa
Protein class
Predicted intracellular proteins, Transporters
Subcellular location
Mitochondria

OverviewNCBI Gene

RICTOR and MTOR (FRAP1; MIM 601231) are components of a protein complex that integrates nutrient- and growth factor-derived signals to regulate cell growth (Sarbassov et al., 2004 [PubMed 15268862]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

1708 residues, UniProt reviewed canonical sequence.

>Q6R327|RICTOR
     1  MAAIGRGRSL KNLRVRGRND SGEENVPLDL TREPSDNLRE ILQNVARLQG VSNMRKLGHL
    61  NNFTKLLCDI GHSEEKLGFH YEDIIICLRL ALLNEAKEVR AAGLRALRYL IQDSSILQKV
   121  LKLKVDYLIA RCIDIQQSNE VERTQALRLV RKMITVNASL FPSSVTNSLI AVGNDGLQER
   181  DRMVRACIAI ICELALQNPE VVALRGGLNT ILKNVIDCQL SRINEALITT ILHLLNHPKT
   241  RQYVRADVEL ERILAPYTDF HYRHSPDTAE GQLKEDREAR FLASKMGIIA TFRSWAGIIN
   301  LCKPGNSGIQ SLIGVLCIPN MEIRRGLLEV LYDIFRLPLP VVTEEFIEAL LSVDPGRFQD
   361  SWRLSDGFVA AEAKTILPHR ARSRPDLMDN YLALILSAFI RNGLLEGLVE VITNSDDHIS
   421  VRATILLGEL LHMANTILPH SHSHHLHCLP TLMNMAASFD IPKEKRLRAS AALNCLKRFH
   481  EMKKRGPKPY SLHLDHIIQK AIATHQKRDQ YLRVQKDIFI LKDTEEALLI NLRDSQVLQH
   541  KENLEWNWNL IGTILKWPNV NLRNYKDEQL HRFVRRLLYF YKPSSKLYAN LDLDFAKAKQ
   601  LTVVGCQFTE FLLESEEDGQ GYLEDLVKDI VQWLNASSGM KPERSLQNNG LLTTLSQHYF
   661  LFIGTLSCHP HGVKMLEKCS VFQCLLNLCS LKNQDHLLKL TVSSLDYSRD GLARVILSKI
   721  LTAATDACRL YATKHLRVLL RANVEFFNNW GIELLVTQLH DKNKTISSEA LDILDEACED
   781  KANLHALIQM KPALSHLGDK GLLLLLRFLS IPKGFSYLNE RGYVAKQLEK WHREYNSKYV
   841  DLIEEQLNEA LTTYRKPVDG DNYVRRSNQR LQRPHVYLPI HLYGQLVHHK TGCHLLEVQN
   901  IITELCRNVR TPDLDKWEEI KKLKASLWAL GNIGSSNWGL NLLQEENVIP DILKLAKQCE
   961  VLSIRGTCVY VLGLIAKTKQ GCDILKCHNW DAVRHSRKHL WPVVPDDVEQ LCNELSSIPS
  1021  TLSLNSESTS SRHNSESESV PSSMFILEDD RFGSSSTSTF FLDINEDTEP TFYDRSGPIK
  1081  DKNSFPFFAS SKLVKNRILN SLTLPNKKHR SSSDPKGGKL SSESKTSNRR IRTLTEPSVD
  1141  FNHSDDFTPI STVQKTLQLE TSFMGNKHIE DTGSTPSIGE NDLKFTKNFG TENHRENTSR
  1201  ERLVVESSTS SHMKIRSQSF NTDTTTSGIS SMSSSPSRET VGVDATTMDT DCGSMSTVVS
  1261  TKTIKTSHYL TPQSNHLSLS KSNSVSLVPP GSSHTLPRRA QSLKAPSIAT IKSLADCNFS
  1321  YTSSRDAFGY ATLKRLQQQR MHPSLSHSEA LASPAKDVLF TDTITMKANS FESRLTPSRF
  1381  MKALSYASLD KEDLLSPINQ NTLQRSSSVR SMVSSATYGG SDDYIGLALP VDINDIFQVK
  1441  DIPYFQTKNI PPHDDRGARA FAHDAGGLPS GTGGLVKNSF HLLRQQMSLT EIMNSIHSDA
  1501  SLFLESTEDT GLQEHTDDNC LYCVCIEILG FQPSNQLSAI CSHSDFQDIP YSDWCEQTIH
  1561  NPLEVVPSKF SGISGCSDGV SQEGSASSTK STELLLGVKT IPDDTPMCRI LLRKEVLRLV
  1621  INLSSSVSTK CHETGLLTIK EKYPQTFDDI CLYSEVSHLL SHCTFRLPCR RFIQELFQDV
  1681  QFLQMHEEAE AVLATPPKQP IVDTSAES

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RICTOR can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.39
Highest tissue expression
24 nTPM

Expression across tissuesHPA

Tissue

  • retina: 24 nTPM
  • bone marrow: 23 nTPM
  • thymus: 12 nTPM
  • skeletal muscle: 11 nTPM
  • tongue: 11 nTPM
  • lymph node: 11 nTPM

Single-cell type

  • neutrophils: 1,006 nCPM
  • myonuclei: 499 nCPM
  • rod photoreceptor cells: 408 nCPM
  • oligodendrocytes: 406 nCPM
  • tuft cells: 357 nCPM
  • epicardial cells: 355 nCPM

Immune cell

  • neutrophil: 31 nTPM
  • basophil: 8.8 nTPM
  • eosinophil: 8.6 nTPM
  • naive CD8 T-cell: 6.1 nTPM
  • naive CD4 T-cell: 5.2 nTPM
  • plasmacytoid DC: 5.1 nTPM

Brain region

  • cerebellum: 52 nTPM
  • white matter: 50 nTPM
  • pons: 37 nTPM
  • basal ganglia: 36 nTPM
  • cerebral cortex: 36 nTPM
  • spinal cord: 35 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about RICTOR.

Disease | GeneticClinVar

2 pathogenic / likely-pathogenic of 193 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.16
gnomAD pLI
1
gnomAD missense Z
3.05
DepMap mean gene effect
-0.47
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 9% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Armadillo-type fold
  • Rapamycin-insensitive companion of mTOR, N-terminal domain
  • Pianissimo family
  • Rapamycin-insensitive companion of mTOR, phosphorylation-site
  • Rapamycin-insensitive companion of mTOR, middle domain
  • Rapamycin-insensitive companion of mTOR, domain 5
  • Rapamycin-insensitive companion of mTOR, domain 4
  • Rapamycin-insensitive companion of mTOR RasGEF_N domain
  • Rapamycin-insensitive companion of mTOR, N-term
  • Rapamycin-insensitive companion of mTOR, phosphorylation-site
  • Rapamycin-insensitive companion of mTOR, middle domain
  • Rapamycin-insensitive companion of mTOR, domain 5

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RICTOR in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RICTOR as an antibody target. Whether an autoantibody or antibody against RICTOR could matter depends on whether native RICTOR is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RICTOR is annotated at the cell surface, where native RICTOR is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label RICTOR as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/RICTOR. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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