Seroatlas · Human Serome Atlas

ARMH4

Armadillo-like helical domain-containing protein 4

Also known as: ARMD4_HUMAN, C14orf37, UT2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q86TY3
Gene: ARMH4
Ensembl: ENSG00000139971
Chromosome: 14
Canonical length: 774 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Plasma membrane
Quaternary structure: Homodimer

OverviewNCBI Gene

Predicted to enable TORC2 complex binding activity. Involved in regulation of inflammatory response. Located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

774 residues, UniProt reviewed canonical sequence.

>Q86TY3|ARMH4
     1  MRGPIVLHIC LAFCSLLLFS VATQCLAFPK IERRREIAHV HAEKGQSDKM NTDDLENSSV
    61  TSKQTPQLVV SEDPMMMSAV PSATSLNKAF SINKETQPGQ AGLMQTERPG VSTPTESGVP
   121  SAEEVFGSSQ PERISPESGL AKAMLTIAIT ATPSLTVDEK EELLTSTNFQ PIVEEITETT
   181  KGFLKYMDNQ SFATESQEGV GLGHSPSSYV NTKEMLTTNP KTEKFEADTD HRTTSFPGAE
   241  STAGSEPGSL TPDKEKPSQM TADNTQAAAT KQPLETSEYT LSVEPETDSL LGAPEVTVSV
   301  STAVPAASAL SDEWDDTKLE SVSRIRTPKL GDNEETQVRT EMSQTAQVSH EGMEGGQPWT
   361  EAAQVALGLP EGETHTGTAL LIAHGNERSP AFTDQSSFTP TSLMEDMKVS IVNLLQSTGD
   421  FTESTKENDA LFFLETTVSV SVYESEADQL LGNTMKDIIT QEMTTAVQEP DATLSMVTQE
   481  QVATLELIRD SGKTEEEKED PSPVSDVPGV TQLSRRWEPL ATTISTTVVP LSFEVTPTVE
   541  EQMDTVTGPN EEFTPVLGSP VTPPGIMVGE PSISPALPAL EASSERRTVV PSITRVNTAA
   601  SYGLDQLESE EGQEDEDEED EEDEDEEEED EEEDEEDKDA DSLDEGLDGD TELPGFTLPG
   661  ITSQEPGLEE GNMDLLEGAT YQVPDALEWE QQNQGLVRSW MEKLKDKAGY MSGMLVPVGV
   721  GIAGALFILG ALYSIKVMNR RRRNGFKRHK RKQREFNSMQ DRVMLLADSS EDEF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ARMH4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.7
Highest tissue expression: 7.8 nTPM

Expression across tissuesHPA

Tissue

kidney: 7.8 nTPM
ovary: 5.1 nTPM
cerebral cortex: 4.7 nTPM
parathyroid gland: 3.4 nTPM
heart muscle: 2.9 nTPM
endometrium: 2.8 nTPM

Single-cell type

podocytes: 1,276 nCPM
cardiomyocytes: 485 nCPM
epicardial cells: 277 nCPM
adipocytes: 176 nCPM
microglia: 170 nCPM
sertoli cells: 164 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

pons: 40 nTPM
cerebellum: 31 nTPM
medulla oblongata: 30 nTPM
midbrain: 24 nTPM
cerebral cortex: 20 nTPM
basal ganglia: 19 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.88
gnomAD pLI: 0
DepMap mean gene effect: 0.04
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Protein domainsUniProt · Pfam · InterPro

Armadillo-like helical domain-containing protein 4
Armadillo-like helical domain-containing protein 4

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ARMH4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ARMH4 as an antibody target. Whether an autoantibody or antibody against ARMH4 could matter depends on whether native ARMH4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ARMH4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ARMH4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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