Seroatlas · Human Serome Atlas

CCDC28B

Coiled-coil domain-containing protein 28B

Also known as: CC28B_HUMAN, MGC1203, RP4-622L5.5

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BUN5
Gene: CCDC28B
Ensembl: ENSG00000160050
Chromosome: 1
Canonical length: 200 aa
Protein class: Disease related genes, Predicted intracellular proteins

OverviewNCBI Gene

The product of this gene localizes to centrosomes and basal bodies. The protein colocalizes with several proteins associated with Bardet-Biedl syndrome (BBS) and participates in the regulation of cilia development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

Canonical amino-acid sequenceUniProt

200 residues, UniProt reviewed canonical sequence.

>Q9BUN5|CCDC28B
     1  MDDKKKKRSP KPCLAQPAQA PGTLRRVPVP TSHSGSLALG LPHLPSPKQR AKFKRVGKEK
    61  CRPVLAGGGS GSAGTPLQHS FLTEVTDVYE MEGGLLNLLN DFHSGRLQAF GKECSFEQLE
   121  HVREMQEKLA RLHFSLDVCG EEEDDEEEED GVTEGLPEEQ KKTMADRNLD QLLSNLEDLS
   181  NSIQKLHLAE NAEPEEQSAA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CCDC28B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.59
Highest tissue expression: 211 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 211 nTPM
tongue: 70 nTPM
cerebellum: 31 nTPM
testis: 27 nTPM
heart muscle: 26 nTPM
pituitary gland: 24 nTPM

Single-cell type

megakaryocytes: 309 nCPM
tuft cells: 104 nCPM
late spermatids: 55 nCPM
megakaryocyte progenitors: 55 nCPM
neuroendocrine cells: 43 nCPM
epicardial cells: 41 nCPM

Immune cell

NK-cell: 47 nTPM
plasmacytoid DC: 37 nTPM
gdT-cell: 36 nTPM
memory CD8 T-cell: 34 nTPM
naive B-cell: 32 nTPM
myeloid DC: 31 nTPM

Brain region

thalamus: 14 nTPM
cerebellum: 11 nTPM
amygdala: 11 nTPM
cerebral cortex: 9.4 nTPM
hypothalamus: 8.5 nTPM
midbrain: 8.4 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about CCDC28B.

Disease | AllUniProt

Conditions CCDC28B is implicated in, by any mechanism.

Bardet-Biedl syndrome (BBS) MIM:209900

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.92
gnomAD pLI: 0
gnomAD missense Z: 1.03
DepMap mean gene effect: -0.19
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

cilium assembly

Cellular components

centrosome

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CCDC28B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CCDC28B as an antibody target. Whether an autoantibody or antibody against CCDC28B could matter depends on whether native CCDC28B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CCDC28B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CCDC28B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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