Seroatlas · Human Serome Atlas

PRR5L

Proline-rich protein 5-like

Also known as: FLJ14213, PROTOR-2, PRR5L_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6MZQ0
Gene: PRR5L
Ensembl: ENSG00000135362
Chromosome: 11
Canonical length: 368 aa
Protein class: Predicted intracellular proteins
Subcellular location: Cytokinetic bridge,Cytosol

OverviewNCBI Gene

Enables ubiquitin protein ligase binding activity. Involved in several processes, including TORC2 signaling; regulation of fibroblast migration; and regulation of primary metabolic process. Part of TORC2 complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

368 residues, UniProt reviewed canonical sequence.

>Q6MZQ0|PRR5L
     1  MTRGFAPILP VEFHKMGSFR RPRPRFMSSP VLSDLPRFQA ARQALQLSSS SAWNSVQTAV
    61  INVFKGGGLQ SNELYALNEN IRRLLKSELG SFITDYFQNQ LLAKGLFFVE EKIKLCEGEN
   121  RIEVLAEVWD HFFTETLPTL QAIFYPVQGQ ELTIRQISLL GFRDLVLLKV KLGDLLLLAQ
   181  SKLPSSIVQM LLILQSVHEP TGPSESYLQL EELVKQVVSP FLGISGDRSF SGPTYTLARR
   241  HSRVRPKVTV LNYASPITAV SRPLNEMVLT PLTEQEGEAY LEKCGSVRRH TVANAHSDIQ
   301  LLAMATMMHS GLGEEASSEN KCLLLPPSFP PPHRQCSSEP NITDNPDGLE EGARGSQEGS
   361  ELNCASLS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PRR5L can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.5
Highest tissue expression: 34 nTPM

Expression across tissuesHPA

Tissue

spleen: 34 nTPM
colon: 33 nTPM
rectum: 26 nTPM
spinal cord: 25 nTPM
lung: 13 nTPM
ovary: 12 nTPM

Single-cell type

oligodendrocytes: 341 nCPM
salivary ionocytes: 116 nCPM
salivary duct cells: 109 nCPM
nk-cells: 104 nCPM
colonocytes: 88 nCPM
lymphatic endothelial cells: 80 nCPM

Immune cell

basophil: 36 nTPM
gdT-cell: 35 nTPM
memory CD8 T-cell: 30 nTPM
eosinophil: 25 nTPM
non-classical monocyte: 25 nTPM
intermediate monocyte: 21 nTPM

Brain region

white matter: 100 nTPM
medulla oblongata: 85 nTPM
pons: 63 nTPM
basal ganglia: 63 nTPM
spinal cord: 57 nTPM
midbrain: 56 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.64
gnomAD pLI: 0.07
gnomAD missense Z: 1.23
DepMap mean gene effect: 0.17
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

ubiquitin protein ligase binding

Cellular components

TORC2 complex

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PRR5L in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PRR5L as an antibody target. Whether an autoantibody or antibody against PRR5L could matter depends on whether native PRR5L is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PRR5L is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PRR5L as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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