Seroatlas · Human Serome Atlas

UBXN2A

UBX domain-containing protein 2A

Also known as: UBX2A_HUMAN, UBXD4

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P68543
Gene: UBXN2A
Ensembl: ENSG00000173960
Chromosome: 2
Canonical length: 259 aa
Protein class: Predicted intracellular proteins
Subcellular location: Centrosome

OverviewNCBI Gene

Predicted to enable ubiquitin binding activity. Involved in negative regulation of ERAD pathway and positive regulation of protein catabolic process. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

259 residues, UniProt reviewed canonical sequence.

>P68543|UBXN2A
     1  MKDVDNLKSI KEEWVCETGS DNQPLGNNQQ SNCEYFVDSL FEEAQKVSSK CVSPAEQKKQ
    61  VDVNIKLWKN GFTVNDDFRS YSDGASQQFL NSIKKGELPS ELQGIFDKEE VDVKVEDKKN
   121  EICLSTKPVF QPFSGQGHRL GSATPKIVSK AKNIEVENKN NLSAVPLNNL EPITNIQIWL
   181  ANGKRIVQKF NITHRVSHIK DFIEKYQGSQ RSPPFSLATA LPVLRLLDET LTLEEADLQN
   241  AVIIQRLQKT ASFRELSEH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against UBXN2A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.47
Highest tissue expression: 10 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 10 nTPM
heart muscle: 7.3 nTPM
tongue: 7.3 nTPM
parathyroid gland: 6.9 nTPM
smooth muscle: 6.4 nTPM
adipose tissue: 5.7 nTPM

Single-cell type

platelets: 181 nCPM
myonuclei: 153 nCPM
esophageal apical cells: 140 nCPM
pdcs: 119 nCPM
fibro-adipogenic progenitors: 114 nCPM
enterocytes: 108 nCPM

Immune cell

basophil: 5 nTPM
NK-cell: 4.8 nTPM
plasmacytoid DC: 4.1 nTPM
memory B-cell: 3.9 nTPM
naive CD4 T-cell: 3.7 nTPM
MAIT T-cell: 3.6 nTPM

Brain region

cerebellum: 17 nTPM
white matter: 17 nTPM
midbrain: 15 nTPM
medulla oblongata: 14 nTPM
pons: 14 nTPM
spinal cord: 14 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.41
gnomAD pLI: 0
gnomAD missense Z: 0.58
DepMap mean gene effect: 0.13
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of UBXN2A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads UBXN2A as an antibody target. Whether an autoantibody or antibody against UBXN2A could matter depends on whether native UBXN2A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

UBXN2A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label UBXN2A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...