Seroatlas · Human Serome Atlas

MAPKAP1

Target of rapamycin complex 2 subunit MAPKAP1

Also known as: MGC2745, MIP1, SIN1, SIN1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9BPZ7
Gene
MAPKAP1
Ensembl
ENSG00000119487
Chromosome
9
Canonical length
522 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Primary cilium,Cytosol

OverviewNCBI Gene

This gene encodes a protein that is highly similar to the yeast SIN1 protein, a stress-activated protein kinase. Alternatively spliced transcript variants encoding distinct isoforms have been described. Alternate polyadenylation sites as well as alternate 3' UTRs have been identified for transcripts of this gene. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

522 residues, UniProt reviewed canonical sequence.

>Q9BPZ7|MAPKAP1
     1  MAFLDNPTII LAHIRQSHVT SDDTGMCEMV LIDHDVDLEK IHPPSMPGDS GSEIQGSNGE
    61  TQGYVYAQSV DITSSWDFGI RRRSNTAQRL ERLRKERQNQ IKCKNIQWKE RNSKQSAQEL
   121  KSLFEKKSLK EKPPISGKQS ILSVRLEQCP LQLNNPFNEY SKFDGKGHVG TTATKKIDVY
   181  LPLHSSQDRL LPMTVVTMAS ARVQDLIGLI CWQYTSEGRE PKLNDNVSAY CLHIAEDDGE
   241  VDTDFPPLDS NEPIHKFGFS TLALVEKYSS PGLTSKESLF VRINAAHGFS LIQVDNTKVT
   301  MKEILLKAVK RRKGSQKVSG PQYRLEKQSE PNVAVDLDST LESQSAWEFC LVRENSSRAD
   361  GVFEEDSQID IATVQDMLSS HHYKSFKVSM IHRLRFTTDV QLGISGDKVE IDPVTNQKAS
   421  TKFWIKQKPI SIDSDLLCAC DLAEEKSPSH AIFKLTYLSN HDYKHLYFES DAATVNEIVL
   481  KVNYILESRA STARADYFAQ KQRKLNRRTS FSFQKEKKSG QQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MAPKAP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.42
Highest tissue expression
97 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 97 nTPM
  • tongue: 71 nTPM
  • heart muscle: 65 nTPM
  • basal ganglia: 51 nTPM
  • parathyroid gland: 50 nTPM
  • adrenal gland: 45 nTPM

Single-cell type

  • renal collecting duct intercalated cells: 248 nCPM
  • proximal tubule cells: 236 nCPM
  • microglia: 227 nCPM
  • choroid plexus epithelial cells: 215 nCPM
  • neutrophil progenitors: 207 nCPM
  • myonuclei: 203 nCPM

Immune cell

  • neutrophil: 19 nTPM
  • memory B-cell: 8.2 nTPM
  • naive B-cell: 7.4 nTPM
  • plasmacytoid DC: 7.2 nTPM
  • naive CD8 T-cell: 7.1 nTPM
  • classical monocyte: 6 nTPM

Brain region

  • thalamus: 86 nTPM
  • medulla oblongata: 77 nTPM
  • basal ganglia: 77 nTPM
  • midbrain: 74 nTPM
  • choroid plexus: 70 nTPM
  • hippocampal formation: 68 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.15
gnomAD pLI
1
gnomAD missense Z
2.83
DepMap mean gene effect
-0.3
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • PH-like domain superfamily
  • TORC2 component Sin1/Avo1
  • SAPK-interacting protein 1, Pleckstrin-homology domain
  • Sin1, middle CRIM domain
  • Sin1, N-terminal
  • Target of rapamycin complex 2 subunit MAPKAP1-like, Ras-binding domain
  • Stress-activated map kinase interacting protein 1 (SIN1)
  • SAPK-interacting protein 1 (Sin1), middle CRIM domain
  • SAPK-interacting protein 1 (Sin1), Pleckstrin-homology
  • SIN1 Ras-binding domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MAPKAP1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MAPKAP1 as an antibody target. Whether an autoantibody or antibody against MAPKAP1 could matter depends on whether native MAPKAP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MAPKAP1 is annotated at the cell surface, where native MAPKAP1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label MAPKAP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/MAPKAP1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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