Seroatlas · Human Serome Atlas

WBP4

WW domain-binding protein 4

Also known as: FBP21, MGC117310, WBP4_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O75554
Gene: WBP4
Ensembl: ENSG00000120688
Chromosome: 13
Canonical length: 376 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Vesicles,Plasma membrane

OverviewNCBI Gene

This gene encodes WW domain-containing binding protein 4. The WW domain represents a small and compact globular structure that interacts with proline-rich ligands. This encoded protein is a general spliceosomal protein that may play a role in cross-intron bridging of U1 and U2 snRNPs in the spliceosomal complex A. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

376 residues, UniProt reviewed canonical sequence.

>O75554|WBP4
     1  MADYWKSQPK KFCDYCKCWI ADNRPSVEFH ERGKNHKENV AKRISEIKQK SLDKAKEEEK
    61  ASKEFAAMEA AALKAYQEDL KRLGLESEIL EPSITPVTST IPPTSTSNQQ KEKKEKKKRK
   121  KDPSKGRWVE GITSEGYHYY YDLISGASQW EKPEGFQGDL KKTAVKTVWV EGLSEDGFTY
   181  YYNTETGESR WEKPDDFIPH TSDLPSSKVN ENSLGTLDES KSSDSHSDSD GEQEAEEGGV
   241  STETEKPKIK FKEKNKNSDG GSDPETQKEK SIQKQNSLGS NEEKSKTLKK SNPYGEWQEI
   301  KQEVESHEEV DLELPSTENE YVSTSEADGG GEPKVVFKEK TVTSLGVMAD GVAPVFKKRR
   361  TENGKSRNLR QRGDDQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against WBP4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.62
Highest tissue expression: 38 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 38 nTPM
tongue: 28 nTPM
heart muscle: 22 nTPM
endometrium: 17 nTPM
adipose tissue: 16 nTPM
spinal cord: 16 nTPM

Single-cell type

epididymal basal cells: 194 nCPM
decidual stromal cells: 139 nCPM
neutrophil progenitors: 115 nCPM
early primary spermatocytes: 112 nCPM
smooth muscle cells: 110 nCPM
epididymal principal cells: 110 nCPM

Immune cell

neutrophil: 27 nTPM
non-classical monocyte: 22 nTPM
basophil: 19 nTPM
plasmacytoid DC: 19 nTPM
naive CD4 T-cell: 15 nTPM
naive CD8 T-cell: 14 nTPM

Brain region

white matter: 22 nTPM
hypothalamus: 21 nTPM
cerebral cortex: 21 nTPM
midbrain: 19 nTPM
basal ganglia: 18 nTPM
medulla oblongata: 18 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about WBP4.

Disease | AllUniProt

Conditions WBP4 is implicated in, by any mechanism.

Neurodevelopmental disorder with hypotonia, feeding difficulties, facial dysmorphism, and brain abnormalities (NEDHFDB) MIM:620852

Disease | GeneticClinVar

6 pathogenic / likely-pathogenic of 86 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Neurodevelopmental disorder
Neurodevelopmental disorder with hypotonia, feeding difficulties, facial dysmorphism, and brain abnormalities

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.02
gnomAD pLI: 0
gnomAD missense Z: 0.24
DepMap mean gene effect: -0.15
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of WBP4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads WBP4 as an antibody target. Whether an autoantibody or antibody against WBP4 could matter depends on whether native WBP4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

WBP4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label WBP4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...