KHDC4/BBP-like, KH-domain type I

Definition

This entry represents eukaryotic type I KH domain. The core KH domain is accompanied by additional alpha-helix and beta-sheet motifs at the C terminus. This entry includes proteins involved in pre-mRNA splicing such as KH domain-containing BBP from fungi, KH homology domain-containing protein 4 (KHDC4, also known as BLOM7) and splicing factor 1 (SF1) from animals, and homologues from plants, including RIK. KHDC4 interacts with the PRP19C/Prp19 complex/NTC/Nineteen complex which is part of the spliceosome. It binds preferentially RNA with A/C rich sequences and poly-C stretches. Branchpoint binding proteins (BBP) from fungi and its mammalian homologue SF1 are required for pre-spliceosome formation [[cite:PMID:11691992],[cite:PMID:15811367],[cite:PMID:24838563],[cite:PMID:23630077],[cite:PMID:25587180]].

6 human proteins with this domain

Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.

Download CSV (6 proteins: gene, accession, name)

• KHDC4
• KHDRBS1
• KHDRBS2
• KHDRBS3
• QKI
• SF1