KH domain-containing BBP-like

Definition

This entry represents a group of KH domain-containing proteins that share protein sequence similarity with fungal BBP protein, such as KH domain-containing RNA-binding protein QKI and KHDR1-3 from human. QKI is a RNA-binding protein that plays a central role in myelination PMID:16641098 and regulates pre-mRNA splicing, mRNA export and protein translation PMID:23630077. BBP/SF1 family members include the branchpoint binding proteins (BBP) from yeast and their mammalian homologue, splicing factor 1 (SF1). They are KH domain containing proteins required for pre-spliceosome formation, which is the first step of pre-mRNA splicing [[cite:PMID:12374752], [cite:PMID:10775271]]. In budding yeasts, BBP binds the conserved RNA sequence UACUAAC, called the branchpoint motif, found near the 3' end of yeast introns PMID:21189690. Besides its function in pre-mRNA splicing, BBP is also involved in nuclear retention of pre-mRNA PMID:10775271. Mammalian SF1, also known as ZFM1, may act as transcription repressor PMID:9660765.

5 human proteins with this domain

Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.

Download CSV (5 proteins: gene, accession, name)

• KHDRBS1
• KHDRBS2
• KHDRBS3
• QKI
• SF1