Seroatlas · Human Serome Atlas

RIN1

Ras and Rab interactor 1

Also known as: RIN1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q13671
Gene: RIN1
Ensembl: ENSG00000174791
Chromosome: 11
Canonical length: 783 aa
Protein class: Predicted intracellular proteins, RAS pathway related proteins

OverviewNCBI Gene

Predicted to enable guanyl-nucleotide exchange factor activity and small GTPase binding activity. Predicted to be involved in signal transduction. Predicted to act upstream of or within associative learning; memory; and negative regulation of synaptic plasticity. Located in cytoplasm and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

783 residues, UniProt reviewed canonical sequence.

>Q13671|RIN1
     1  MESPGESGAG SPGAPSPSSF TTGHLAREKP AQDPLYDVPN ASGGQAGGPQ RPGRVVSLRE
    61  RLLLTRPVWL QLQANAAAAL HMLRTEPPGT FLVRKSNTRQ CQALCMRLPE ASGPSFVSSH
   121  YILESPGGVS LEGSELMFPD LVQLICAYCH TRDILLLPLQ LPRAIHHAAT HKELEAISHL
   181  GIEFWSSSLN IKAQRGPAGG PVLPQLKARS PQELDQGTGA ALCFFNPLFP GDLGPTKREK
   241  FKRSFKVRVS TETSSPLSPP AVPPPPVPVL PGAVPSQTER LPPCQLLRRE SSVGYRVPAG
   301  SGPSLPPMPS LQEVDCGSPS SSEEEGVPGS RGSPATSPHL GRRRPLLRSM SAAFCSLLAP
   361  ERQVGRAAAA LMQDRHTAAG QLVQDLLTQV RAGPEPQELQ GIRQALSRAR AMLSAELGPE
   421  KLLSPKRLEH VLEKSLHCSV LKPLRPILAA RLRRRLAADG SLGRLAEGLR LARAQGPGAF
   481  GSHLSLPSPV ELEQVRQKLL QLLRTYSPSA QVKRLLQACK LLYMALRTQE GEGAGADEFL
   541  PLLSLVLAHC DLPELLLEAE YMSELLEPSL LTGEGGYYLT SLSASLALLS GLGQAHTLPL
   601  SPVQELRRSL SLWEQRRLPA THCFQHLLRV AYQDPSSGCT SKTLAVPPEA SIATLNQLCA
   661  TKFRVTQPNT FGLFLYKEQG YHRLPPGALA HRLPTTGYLV YRRAEWPETQ GAVTEEEGSG
   721  QSEARSRGEE QGCQGDGDAG VKASPRDIRE QSETTAEGGQ GQAQEGPAQP GEPEAEGSRA
   781  AEE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RIN1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.44
Highest tissue expression: 9 nTPM

Expression across tissuesHPA

Tissue

skin: 9 nTPM
esophagus: 5.9 nTPM
basal ganglia: 5.7 nTPM
hippocampal formation: 4.2 nTPM
cerebellum: 3.5 nTPM
amygdala: 3 nTPM

Single-cell type

esophageal basal cells: 55 nCPM
thymic myoid cells: 23 nCPM
basal keratinocytes: 21 nCPM
esophageal suprabasal cells: 17 nCPM
brain excitatory neurons: 17 nCPM
fallopian tube ciliated cells: 17 nCPM

Immune cell

non-classical monocyte: 9.8 nTPM
intermediate monocyte: 4.7 nTPM
classical monocyte: 2.7 nTPM
total PBMC: 1.8 nTPM
myeloid DC: 1.7 nTPM
MAIT T-cell: 0.6 nTPM

Brain region

hippocampal formation: 13 nTPM
cerebral cortex: 12 nTPM
basal ganglia: 10 nTPM
amygdala: 7.6 nTPM
cerebellum: 6.7 nTPM
white matter: 5.2 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about RIN1.

Disease | ImmuneIEDB

Conditions an epitope on RIN1 was assayed in.

colonic benign neoplasm T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.92
gnomAD pLI: 0
gnomAD missense Z: 0.55
DepMap mean gene effect: -0.21
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Ras-associating domain
SH2 domain
VPS9 domain
SH2 domain superfamily
VPS9 domain superfamily
Vacuolar protein sorting-associated protein 9-like
Ras association (RalGDS/AF-6) domain
Vacuolar sorting protein 9 (VPS9) domain
RIN1-like domain
Ras and Rab interactor 1, SH2 domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RIN1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RIN1 as an antibody target. Whether an autoantibody or antibody against RIN1 could matter depends on whether native RIN1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RIN1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RIN1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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