Seroatlas · Human Serome Atlas

PIK3CG

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform

Also known as: PK3CG_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P48736
Gene: PIK3CG
Ensembl: ENSG00000105851
Chromosome: 7
Canonical length: 1102 aa
Protein class: Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Metabolic proteins, Predicted intracellular proteins
Subcellular location: Plasma membrane,Cytosol

OverviewNCBI Gene

Phosphoinositide 3-kinases (PI3Ks) phosphorylate inositol lipids and are involved in the immune response. The protein encoded by this gene is a class I catalytic subunit of PI3K. Like other class I catalytic subunits (p110-alpha p110-beta, and p110-delta), the encoded protein binds a p85 regulatory subunit to form PI3K. This gene is located in a commonly deleted segment of chromosome 7 previously identified in myeloid leukemias. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jun 2015]

Canonical amino-acid sequenceUniProt

1102 residues, UniProt reviewed canonical sequence.

>P48736|PIK3CG
     1  MELENYKQPV VLREDNCRRR RRMKPRSAAA SLSSMELIPI EFVLPTSQRK CKSPETALLH
    61  VAGHGNVEQM KAQVWLRALE TSVAADFYHR LGPHHFLLLY QKKGQWYEIY DKYQVVQTLD
   121  CLRYWKATHR SPGQIHLVQR HPPSEESQAF QRQLTALIGY DVTDVSNVHD DELEFTRRGL
   181  VTPRMAEVAS RDPKLYAMHP WVTSKPLPEY LWKKIANNCI FIVIHRSTTS QTIKVSPDDT
   241  PGAILQSFFT KMAKKKSLMD IPESQSEQDF VLRVCGRDEY LVGETPIKNF QWVRHCLKNG
   301  EEIHVVLDTP PDPALDEVRK EEWPLVDDCT GVTGYHEQLT IHGKDHESVF TVSLWDCDRK
   361  FRVKIRGIDI PVLPRNTDLT VFVEANIQHG QQVLCQRRTS PKPFTEEVLW NVWLEFSIKI
   421  KDLPKGALLN LQIYCGKAPA LSSKASAESP SSESKGKVQL LYYVNLLLID HRFLLRRGEY
   481  VLHMWQISGK GEDQGSFNAD KLTSATNPDK ENSMSISILL DNYCHPIALP KHQPTPDPEG
   541  DRVRAEMPNQ LRKQLEAIIA TDPLNPLTAE DKELLWHFRY ESLKHPKAYP KLFSSVKWGQ
   601  QEIVAKTYQL LARREVWDQS ALDVGLTMQL LDCNFSDENV RAIAVQKLES LEDDDVLHYL
   661  LQLVQAVKFE PYHDSALARF LLKRGLRNKR IGHFLFWFLR SEIAQSRHYQ QRFAVILEAY
   721  LRGCGTAMLH DFTQQVQVIE MLQKVTLDIK SLSAEKYDVS SQVISQLKQK LENLQNSQLP
   781  ESFRVPYDPG LKAGALAIEK CKVMASKKKP LWLEFKCADP TALSNETIGI IFKHGDDLRQ
   841  DMLILQILRI MESIWETESL DLCLLPYGCI STGDKIGMIE IVKDATTIAK IQQSTVGNTG
   901  AFKDEVLNHW LKEKSPTEEK FQAAVERFVY SCAGYCVATF VLGIGDRHND NIMITETGNL
   961  FHIDFGHILG NYKSFLGINK ERVPFVLTPD FLFVMGTSGK KTSPHFQKFQ DICVKAYLAL
  1021  RHHTNLLIIL FSMMLMTGMP QLTSKEDIEY IRDALTVGKN EEDAKKYFLD QIEVCRDKGW
  1081  TVQFNWFLHL VLGIKQGEKH SA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PIK3CG can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.25
Highest tissue expression: 41 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 41 nTPM
tonsil: 18 nTPM
lymph node: 18 nTPM
thymus: 15 nTPM
appendix: 11 nTPM
spleen: 10 nTPM

Single-cell type

tuft cells: 565 nCPM
neutrophil progenitors: 331 nCPM
neutrophils: 327 nCPM
plasma cells: 147 nCPM
pdcs: 112 nCPM
monocyte progenitors: 83 nCPM

Immune cell

non-classical monocyte: 44 nTPM
eosinophil: 24 nTPM
neutrophil: 23 nTPM
intermediate monocyte: 18 nTPM
basophil: 11 nTPM
naive B-cell: 10 nTPM

Brain region

white matter: 10 nTPM
medulla oblongata: 7.3 nTPM
thalamus: 6 nTPM
spinal cord: 5.6 nTPM
pons: 5.2 nTPM
cerebral cortex: 4.5 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about PIK3CG.

Disease | AllUniProt

Conditions PIK3CG is implicated in, by any mechanism.

Immunodeficiency 97 with autoinflammation (IMD97) MIM:619802

Disease | GeneticClinVar

4 pathogenic / likely-pathogenic of 159 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Immunodeficiency 97 with autoinflammation

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.6
gnomAD pLI: 0
gnomAD missense Z: 1.97
DepMap mean gene effect: -0.09
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PIK3CG in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PIK3CG as an antibody target. Whether an autoantibody or antibody against PIK3CG could matter depends on whether native PIK3CG is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PIK3CG is annotated at the cell surface, where native PIK3CG is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label PIK3CG as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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