Seroatlas · Human Serome Atlas

TBC1D10C

Carabin

Also known as: Carabin, EPI64C, FLJ00332, TB10C_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8IV04
Gene
TBC1D10C
Ensembl
ENSG00000175463
Chromosome
11
Canonical length
446 aa
Protein class
Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Nuclear bodies

OverviewNCBI Gene

The protein encoded by this gene has an N-terminal Rab-GTPase domain and a binding site at the C-terminus for calcineurin, and is an inhibitor of both the Ras signaling pathway and calcineurin, a phosphatase regulated by calcium and calmodulin. Genes encoding similar proteins are located on chromosomes 16 and 22. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2013]

Canonical amino-acid sequenceUniProt

446 residues, UniProt reviewed canonical sequence.

>Q8IV04|TBC1D10C
     1  MAQALGEDLV QPPELQDDSS SLGSDSELSG PGPYRQADRY GFIGGSSAEP GPGHPPADLI
    61  RQREMKWVEM TSHWEKTMSR RYKKVKMQCR KGIPSALRAR CWPLLCGAHV CQKNSPGTYQ
   121  ELAEAPGDPQ WMETIGRDLH RQFPLHEMFV SPQGHGQQGL LQVLKAYTLY RPEQGYCQAQ
   181  GPVAAVLLMH LPPEEAFWCL VQICEVYLPG YYGPHMEAVR LDAEVFMALL RRLLPHVHKH
   241  LQQVGVGPLL YLPEWFLCLF ARSLPFPTVL RVWDAFLSEG ARVLFRVGLT LVRLALGTAE
   301  QRGACPGLLE TLGALRAIPP AQLQEEAFMS QVHSVVLSER DLQREIKAQL AQLPDSAPGP
   361  PPRPQVRLAG AQAIFEAQQL AGVRRGAKPE VPRIVVQPPE EPRPPRRKPQ TRGKTFHGLL
   421  TRARGPPIEG PPRPQRGSTS FLDTRF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TBC1D10C can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.34
Highest tissue expression
68 nTPM

Expression across tissuesHPA

Tissue

  • spleen: 68 nTPM
  • lymph node: 53 nTPM
  • thymus: 43 nTPM
  • bone marrow: 38 nTPM
  • small intestine: 30 nTPM
  • appendix: 24 nTPM

Single-cell type

  • nk-cells: 112 nCPM
  • t-cells: 109 nCPM
  • b-cells: 83 nCPM
  • neutrophils: 72 nCPM
  • neutrophil progenitors: 65 nCPM
  • innate lymphoid cells: 50 nCPM

Immune cell

  • T-reg: 287 nTPM
  • eosinophil: 271 nTPM
  • total PBMC: 261 nTPM
  • neutrophil: 239 nTPM
  • gdT-cell: 238 nTPM
  • memory CD8 T-cell: 208 nTPM

Brain region

  • basal ganglia: 2.7 nTPM
  • white matter: 2.6 nTPM
  • medulla oblongata: 2 nTPM
  • cerebral cortex: 1.9 nTPM
  • choroid plexus: 1.8 nTPM
  • thalamus: 1.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.51
gnomAD pLI
0.15
gnomAD missense Z
0.92
DepMap mean gene effect
-0.29
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TBC1D10C in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TBC1D10C as an antibody target. Whether an autoantibody or antibody against TBC1D10C could matter depends on whether native TBC1D10C is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TBC1D10C is annotated at the cell surface, where native TBC1D10C is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label TBC1D10C as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TBC1D10C. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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