Seroatlas · Human Serome Atlas

RASIP1

Ras-interacting protein 1

Also known as: FLJ20401, RAIN, RAIN_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q5U651
Gene
RASIP1
Ensembl
ENSG00000105538
Chromosome
19
Canonical length
963 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

Enables GTPase binding activity and protein homodimerization activity. Involved in several processes, including negative regulation of Rho protein signal transduction; negative regulation of metabolic process; and positive regulation of integrin activation. Located in cell-cell junction. Part of protein-containing complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

963 residues, UniProt reviewed canonical sequence.

>Q5U651|RASIP1
     1  MLSGERKEGG SPRFGKLHLP VGLWINSPRK QLAKLGRRWP SAASVKSSSS DTGSRSSEPL
    61  PPPPPHVELR RVGAVKAAGG ASGSRAKRIS QLFRGSGTGT TGSSGAGGPG TPGGAQRWAS
   121  EKKLPELAAG VAPEPPLATR ATAPPGVLKI FGAGLASGAN YKSVLATARS TARELVAEAL
   181  ERYGLAGSPG GGPGESSCVD AFALCDALGR PAAAGVGSGE WRAEHLRVLG DSERPLLVQE
   241  LWRARPGWAR RFELRGREEA RRLEQEAFGA ADSEGTGAPS WRPQKNRSRA ASGGAALASP
   301  GPGTGSGAPA GSGGKERSEN LSLRRSVSEL SLQGRRRRQQ ERRQQALSMA PGAADAQIGT
   361  ADPGDFDQLT QCLIQAPSNR PYFLLLQGYQ DAQDFVVYVM TREQHVFGRG GNSSGRGGSP
   421  APYVDTFLNA PDILPRHCTV RAGPEHPAMV RPSRGAPVTH NGCLLLREAE LHPGDLLGLG
   481  EHFLFMYKDP RTGGSGPARP PWLPARPGAT PPGPGWAFSC RLCGRGLQER GEALAAYLDG
   541  REPVLRFRPR EEEALLGEIV RAAAAGSGDL PPLGPATLLA LCVQHSAREL ELGHLPRLLG
   601  RLARLIKEAV WEKIKEIGDR QPENHPEGVP EVPLTPEAVS VELRPLMLWM ANTTELLSFV
   661  QEKVLEMEKE ADQEDPQLCN DLELCDEAMA LLDEVIMCTF QQSVYYLTKT LYSTLPALLD
   721  SNPFTAGAEL PGPGAELGAM PPGLRPTLGV FQAALELTSQ CELHPDLVSQ TFGYLFFFSN
   781  ASLLNSLMER GQGRPFYQWS RAVQIRTNLD LVLDWLQGAG LGDIATEFFR KLSMAVNLLC
   841  VPRTSLLKAS WSSLRTDHPT LTPAQLHHLL SHYQLGPGRG PPAAWDPPPA EREAVDTGDI
   901  FESFSSHPPL ILPLGSSRLR LTGPVTDDAL HRELRRLRRL LWDLEQQELP ANYRHGPPVA
   961  TSP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RASIP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.39
Highest tissue expression
28 nTPM

Expression across tissuesHPA

Tissue

  • lung: 28 nTPM
  • adipose tissue: 24 nTPM
  • breast: 22 nTPM
  • heart muscle: 19 nTPM
  • spleen: 17 nTPM
  • pancreas: 13 nTPM

Single-cell type

  • vascular endothelial cells: 145 nCPM
  • lymphatic endothelial cells: 115 nCPM
  • parietal cells: 34 nCPM
  • breast myoepithelial cells: 23 nCPM
  • esophageal basal cells: 23 nCPM
  • melanocytes: 22 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • thalamus: 16 nTPM
  • amygdala: 13 nTPM
  • pons: 13 nTPM
  • midbrain: 12 nTPM
  • medulla oblongata: 10 nTPM
  • cerebral cortex: 9.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.25
gnomAD pLI
1
gnomAD missense Z
2.82
DepMap mean gene effect
-0.05
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RASIP1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RASIP1 as an antibody target. Whether an autoantibody or antibody against RASIP1 could matter depends on whether native RASIP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RASIP1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RASIP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/RASIP1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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