Seroatlas · Human Serome Atlas

ZMYND8

MYND-type zinc finger-containing chromatin reader ZMYND8

Also known as: KIAA1125, PRKCBP1, RACK7, ZMYD8_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9ULU4
Gene: ZMYND8
Ensembl: ENSG00000101040
Chromosome: 20
Canonical length: 1186 aa
Protein class: Disease related genes, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nucleoli
Quaternary structure: Homodimer

OverviewNCBI Gene

The protein encoded by this gene is a receptor for activated C-kinase (RACK) protein. The encoded protein has been shown to bind in vitro to activated protein kinase C beta I. In addition, this protein is a cutaneous T-cell lymphoma-associated antigen. Finally, the protein contains a bromodomain and two zinc fingers, and is thought to be a transcriptional regulator. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

1186 residues, UniProt reviewed canonical sequence.

>Q9ULU4|ZMYND8
     1  MDISTRSKDP GSAERTAQKR KFPSPPHSSN GHSPQDTSTS PIKKKKKPGL LNSNNKEQSE
    61  LRHGPFYYMK QPLTTDPVDV VPQDGRNDFY CWVCHREGQV LCCELCPRVY HAKCLRLTSE
   121  PEGDWFCPEC EKITVAECIE TQSKAMTMLT IEQLSYLLKF AIQKMKQPGT DAFQKPVPLE
   181  QHPDYAEYIF HPMDLCTLEK NAKKKMYGCT EAFLADAKWI LHNCIIYNGG NHKLTQIAKV
   241  VIKICEHEMN EIEVCPECYL AACQKRDNWF CEPCSNPHPL VWAKLKGFPF WPAKALRDKD
   301  GQVDARFFGQ HDRAWVPINN CYLMSKEIPF SVKKTKSIFN SAMQEMEVYV ENIRRKFGVF
   361  NYSPFRTPYT PNSQYQMLLD PTNPSAGTAK IDKQEKVKLN FDMTASPKIL MSKPVLSGGT
   421  GRRISLSDMP RSPMSTNSSV HTGSDVEQDA EKKATSSHFS ASEESMDFLD KSTASPASTK
   481  TGQAGSLSGS PKPFSPQLSA PITTKTDKTS TTGSILNLNL DRSKAEMDLK ELSESVQQQS
   541  TPVPLISPKR QIRSRFQLNL DKTIESCKAQ LGINEISEDV YTAVEHSDSE DSEKSDSSDS
   601  EYISDDEQKS KNEPEDTEDK EGCQMDKEPS AVKKKPKPTN PVEIKEELKS TSPASEKADP
   661  GAVKDKASPE PEKDFSEKAK PSPHPIKDKL KGKDETDSPT VHLGLDSDSE SELVIDLGED
   721  HSGREGRKNK KEPKEPSPKQ DVVGKTPPST TVGSHSPPET PVLTRSSAQT SAAGATATTS
   781  TSSTVTVTAP APAATGSPVK KQRPLLPKET APAVQRVVWN SSSKFQTSSQ KWHMQKMQRQ
   841  QQQQQQQNQQ QQPQSSQGTR YQTRQAVKAV QQKEITQSPS TSTITLVTST QSSPLVTSSG
   901  SMSTLVSSVN ADLPIATASA DVAADIAKYT SKMMDAIKGT MTEIYNDLSK NTTGSTIAEI
   961  RRLRIEIEKL QWLHQQELSE MKHNLELTMA EMRQSLEQER DRLIAEVKKQ LELEKQQAVD
  1021  ETKKKQWCAN CKKEAIFYCC WNTSYCDYPC QQAHWPEHMK SCTQSATAPQ QEADAEVNTE
  1081  TLNKSSQGSS SSTQSAPSET ASASKEKETS AEKSKESGST LDLSGSRETP SSILLGSNQG
  1141  SDHSRSNKSS WSSSDEKRGS TRSDHNTSTS TKSLLPKESR LDTFWD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZMYND8 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.55
Highest tissue expression: 31 nTPM

Expression across tissuesHPA

Tissue

epididymis: 31 nTPM
adrenal gland: 31 nTPM
pituitary gland: 25 nTPM
bone marrow: 24 nTPM
choroid plexus: 21 nTPM
cerebellum: 21 nTPM

Single-cell type

megakaryocyte-erythroid progenitors: 597 nCPM
megakaryocyte progenitors: 564 nCPM
sertoli cells: 527 nCPM
cone photoreceptor cells: 503 nCPM
adrenal cortex cells: 447 nCPM
corticotrophs: 406 nCPM

Immune cell

basophil: 35 nTPM
neutrophil: 20 nTPM
naive B-cell: 18 nTPM
plasmacytoid DC: 17 nTPM
NK-cell: 17 nTPM
memory B-cell: 16 nTPM

Brain region

choroid plexus: 149 nTPM
white matter: 123 nTPM
cerebral cortex: 123 nTPM
hippocampal formation: 123 nTPM
pons: 118 nTPM
hypothalamus: 111 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about ZMYND8.

Disease | GeneticClinVar

6 pathogenic / likely-pathogenic of 207 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.13
gnomAD pLI: 1
gnomAD missense Z: 4.04
DepMap mean gene effect: -0.32
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 10% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

PWWP domain
Bromodomain
Zinc finger, PHD-type
Zinc finger, MYND-type
Zinc finger, FYVE/PHD-type
Zinc finger, RING/FYVE/PHD-type
Zinc finger, PHD-type, conserved site
Zinc finger, PHD-finger
Bromodomain-like superfamily
ZMYND11/ZMYD8, MYND zinc finger
Bromodomain
PHD-finger
PWWP domain
ZMYND11/ZMYD8, MYND zinc finger
MYND-type zinc finger-containing chromatin reader ZMYND8
ZMYND8, Bromo domain
PRKCBP1, PHD finger
ZMYND8, coiled-coil
Protein kinase C-binding protein 1
ZMYND8 protein coiled-coil

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZMYND8 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZMYND8 as an antibody target. Whether an autoantibody or antibody against ZMYND8 could matter depends on whether native ZMYND8 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZMYND8 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZMYND8 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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