Seroatlas · Human Serome Atlas

CBFA2T3

Protein CBFA2T3

Also known as: ETO2, MTG16, MTG16_HUMAN, MTGR2, RUNX1T3, ZMYND4

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O75081
Gene
CBFA2T3
Ensembl
ENSG00000129993
Chromosome
16
Canonical length
653 aa
Protein class
Cancer-related genes, Disease related genes, Predicted intracellular proteins
Subcellular location
Nucleoplasm
Quaternary structure
Homotetramer

OverviewNCBI Gene

This gene encodes a member of the myeloid translocation gene family which interact with DNA-bound transcription factors and recruit a range of corepressors to facilitate transcriptional repression. The t(16;21)(q24;q22) translocation is one of the less common karyotypic abnormalities in acute myeloid leukemia. The translocation produces a chimeric gene made up of the 5'-region of the runt-related transcription factor 1 gene fused to the 3'-region of this gene. This gene is also a putative breast tumor suppressor. Alternative splicing results in transcript variants. [provided by RefSeq, Nov 2010]

Canonical amino-acid sequenceUniProt

653 residues, UniProt reviewed canonical sequence.

>O75081|CBFA2T3
     1  MPASRLRDRA ASSASGSTCG SMSQTHPVLE SGLLASAGCS APRGPRKGGP APVDRKAKAS
    61  AMPDSPAEVK TQPRSTPPSM PPPPPAASQG ATRPPSFTPH THREDGPATL PHGRFHGCLK
   121  WSMVCLLMNG SSHSPTAING APCTPNGFSN GPATSSTASL STQHLPPACG ARQLSKLKRF
   181  LTTLQQFGSD ISPEIGERVR TLVLGLVNST LTIEEFHSKL QEATNFPLRP FVIPFLKANL
   241  PLLQRELLHC ARLAKQTPAQ YLAQHEQLLL DASASSPIDS SELLLEVNEN GKRRTPDRTK
   301  ENGSDRDPLH PEHLSKRPCT LNPAQRYSPS NGPPQPTPPP HYRLEDIAMA HHFRDAYRHP
   361  DPRELRERHR PLVVPGSRQE EVIDHKLTER EWAEEWKHLN NLLNCIMDMV EKTRRSLTVL
   421  RRCQEADREE LNHWARRYSD AEDTKKGPAP AAARPRSSSA GPEGPQLDVP REFLPRTLTG
   481  YVPEDIWRKA EEAVNEVKRQ AMSELQKAVS DAERKAHELI TTERAKMERA LAEAKRQASE
   541  DALTVINQQE DSSESCWNCG RKASETCSGC NAARYCGSFC QHRDWEKHHH VCGQSLQGPT
   601  AVVADPVPGP PEAAHSLGPS LPVGAASPSE AGSAGPSRPG SPSPPGPLDT VPR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CBFA2T3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.59
Highest tissue expression
37 nTPM

Expression across tissuesHPA

Tissue

  • cerebellum: 37 nTPM
  • thymus: 27 nTPM
  • pancreas: 26 nTPM
  • spleen: 17 nTPM
  • heart muscle: 16 nTPM
  • skeletal muscle: 13 nTPM

Single-cell type

  • megakaryocyte-erythroid progenitors: 205 nCPM
  • pdcs: 166 nCPM
  • megakaryocyte progenitors: 137 nCPM
  • hematopoietic stem cells: 100 nCPM
  • cdc: 100 nCPM
  • thymocytes: 74 nCPM

Immune cell

  • plasmacytoid DC: 11 nTPM
  • myeloid DC: 6.6 nTPM
  • non-classical monocyte: 4.9 nTPM
  • neutrophil: 3.4 nTPM
  • memory B-cell: 3.1 nTPM
  • intermediate monocyte: 2.8 nTPM

Brain region

  • cerebellum: 102 nTPM
  • cerebral cortex: 44 nTPM
  • basal ganglia: 36 nTPM
  • hippocampal formation: 35 nTPM
  • amygdala: 33 nTPM
  • white matter: 28 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.5
gnomAD pLI
0.05
gnomAD missense Z
0.16
DepMap mean gene effect
0.06
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CBFA2T3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CBFA2T3 as an antibody target. Whether an autoantibody or antibody against CBFA2T3 could matter depends on whether native CBFA2T3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CBFA2T3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CBFA2T3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CBFA2T3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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