Seroatlas · Human Serome Atlas

HDAC10

Polyamine deacetylase HDAC10

Also known as: DKFZP761B039, HDA10_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q969S8
Gene: HDAC10
Ensembl: ENSG00000100429
Chromosome: 22
Canonical length: 669 aa
Protein class: Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

The protein encoded by this gene belongs to the histone deacetylase family, members of which deacetylate lysine residues on the N-terminal part of the core histones. Histone deacetylation modulates chromatin structure, and plays an important role in transcriptional regulation, cell cycle progression, and developmental events. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]

Canonical amino-acid sequenceUniProt

669 residues, UniProt reviewed canonical sequence.

>Q969S8|HDAC10
     1  MGTALVYHED MTATRLLWDD PECEIERPER LTAALDRLRQ RGLEQRCLRL SAREASEEEL
    61  GLVHSPEYVS LVRETQVLGK EELQALSGQF DAIYFHPSTF HCARLAAGAG LQLVDAVLTG
   121  AVQNGLALVR PPGHHGQRAA ANGFCVFNNV AIAAAHAKQK HGLHRILVVD WDVHHGQGIQ
   181  YLFEDDPSVL YFSWHRYEHG RFWPFLRESD ADAVGRGQGL GFTVNLPWNQ VGMGNADYVA
   241  AFLHLLLPLA FEFDPELVLV SAGFDSAIGD PEGQMQATPE CFAHLTQLLQ VLAGGRVCAV
   301  LEGGYHLESL AESVCMTVQT LLGDPAPPLS GPMAPCQSAL ESIQSARAAQ APHWKSLQQQ
   361  DVTAVPMSPS SHSPEGRPPP LLPGGPVCKA AASAPSSLLD QPCLCPAPSV RTAVALTTPD
   421  ITLVLPPDVI QQEASALREE TEAWARPHES LAREEALTAL GKLLYLLDGM LDGQVNSGIA
   481  ATPASAAAAT LDVAVRRGLS HGAQRLLCVA LGQLDRPPDL AHDGRSLWLN IRGKEAAALS
   541  MFHVSTPLPV MTGGFLSCIL GLVLPLAYGF QPDLVLVALG PGHGLQGPHA ALLAAMLRGL
   601  AGGRVLALLE ENSTPQLAGI LARVLNGEAP PSLGPSSVAS PEDVQALMYL RGQLEPQWKM
   661  LQCHPHLVA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HDAC10 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.21
Highest tissue expression: 18 nTPM

Expression across tissuesHPA

Tissue

spleen: 18 nTPM
liver: 17 nTPM
pituitary gland: 13 nTPM
small intestine: 13 nTPM
kidney: 12 nTPM
pancreas: 12 nTPM

Single-cell type

hofbauer cells: 25 nCPM
breast lactating cells: 24 nCPM
enterocytes: 24 nCPM
tuft cells: 23 nCPM
parietal cells: 23 nCPM
foveolar cells: 23 nCPM

Immune cell

eosinophil: 2.5 nTPM
intermediate monocyte: 1.8 nTPM
classical monocyte: 1.6 nTPM
myeloid DC: 1.3 nTPM
plasmacytoid DC: 1.2 nTPM
total PBMC: 1.1 nTPM

Brain region

choroid plexus: 8.5 nTPM
medulla oblongata: 8.1 nTPM
thalamus: 7.9 nTPM
cerebral cortex: 7.7 nTPM
basal ganglia: 7.2 nTPM
amygdala: 7.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.51
gnomAD pLI: 0
gnomAD missense Z: -0.45
DepMap mean gene effect: 0
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

chromatin organization
DNA repair
homologous recombination
macroautophagy
negative regulation of DNA-templated transcription
negative regulation of transcription by RNA polymerase II
positive regulation of mismatch repair
regulation of DNA-templated transcription
polyamine deacetylation
spermidine deacetylation

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of HDAC10 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads HDAC10 as an antibody target. Whether an autoantibody or antibody against HDAC10 could matter depends on whether native HDAC10 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

HDAC10 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label HDAC10 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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