Seroatlas · Human Serome Atlas

INSM1

Insulinoma-associated protein 1

Also known as: IA-1, IA1, INSM1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q01101
Gene
INSM1
Ensembl
ENSG00000173404
Chromosome
20
Canonical length
510 aa
Protein class
Predicted intracellular proteins, Transcription factors

OverviewNCBI Gene

Insulinoma-associated 1 (INSM1) gene is intronless and encodes a protein containing both a zinc finger DNA-binding domain and a putative prohormone domain. This gene is a sensitive marker for neuroendocrine differentiation of human lung tumors. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

510 residues, UniProt reviewed canonical sequence.

>Q01101|INSM1
     1  MPRGFLVKRS KKSTPVSYRV RGGEDGDRAL LLSPSCGGAR AEPPAPSPVP GPLPPPPPAE
    61  RAHAALAAAL ACAPGPQPPP QGPRAAHFGN PEAAHPAPLY SPTRPVSREH EKHKYFERSF
   121  NLGSPVSAES FPTPAALLGG GGGGGASGAG GGGTCGGDPL LFAPAELKMG TAFSAGAEAA
   181  RGPGPGPPLP PAAALRPPGK RPPPPTAAEP PAKAVKAPGA KKPKAIRKLH FEDEVTTSPV
   241  LGLKIKEGPV EAPRGRAGGA ARPLGEFICQ LCKEEYADPF ALAQHKCSRI VRVEYRCPEC
   301  AKVFSCPANL ASHRRWHKPR PAPAAARAPE PEAAARAEAR EAPGGGSDRD TPSPGGVSES
   361  GSEDGLYECH HCAKKFRRQA YLRKHLLAHH QALQAKGAPL APPAEDLLAL YPGPDEKAPQ
   421  EAAGDGEGAG VLGLSASAEC HLCPVCGESF ASKGAQERHL RLLHAAQVFP CKYCPATFYS
   481  SPGLTRHINK CHPSENRQVI LLQVPVRPAC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against INSM1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.65
Highest tissue expression
27 nTPM

Expression across tissuesHPA

Tissue

  • pituitary gland: 27 nTPM
  • cerebellum: 15 nTPM
  • adrenal gland: 6.7 nTPM
  • hypothalamus: 5.3 nTPM
  • basal ganglia: 4.8 nTPM
  • stomach: 4.8 nTPM

Single-cell type

  • neuroendocrine cells: 293 nCPM
  • pancreatic islet cells: 85 nCPM
  • adrenal medulla cells: 75 nCPM
  • corticotrophs: 50 nCPM
  • thyrotrophs: 19 nCPM
  • lactotrophs: 18 nCPM

Immune cell

  • plasmacytoid DC: 0.1 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM

Brain region

  • cerebellum: 29 nTPM
  • basal ganglia: 13 nTPM
  • hypothalamus: 10 nTPM
  • cerebral cortex: 5.7 nTPM
  • midbrain: 5.7 nTPM
  • white matter: 5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.81
gnomAD pLI
0.27
gnomAD missense Z
1.12
DepMap mean gene effect
0.02
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of INSM1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads INSM1 as an antibody target. Whether an autoantibody or antibody against INSM1 could matter depends on whether native INSM1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

INSM1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label INSM1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/INSM1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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