Seroatlas · Human Serome Atlas

PIMREG

Protein PIMREG

Also known as: CATS, FAM64A, FLJ10156, FLJ10491, PIMRE_HUMAN, RCS1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BSJ6
Gene: PIMREG
Ensembl: ENSG00000129195
Chromosome: 17
Canonical length: 248 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Predicted to be involved in cell division. Located in nucleolus and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

248 residues, UniProt reviewed canonical sequence.

>Q9BSJ6|PIMREG
     1  MASRWQNMGT SVRRRSLQHQ EQLEDSKELQ PVVSHQETSV GALGSLCRQF QRRLPLRAVN
    61  LNLRAGPSWK RLETPEPGQQ GLQAAARSAK SALGAVSQRI QESCQSGTKW LVETQVKARR
   121  RKRGAQKGSG SPTHSLSQKS TRLSGAAPAH SAADPWEKEH HRLSVRMGSH AHPLRRSRRE
   181  AAFRSPYSST EPLCSPSESD SDLEPVGAGI QHLQKLSQEL DEAIMAEERK QALSDRQGFI
   241  LKDVYASP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PIMREG can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.66
Highest tissue expression: 13 nTPM

Expression across tissuesHPA

Tissue

thymus: 13 nTPM
spleen: 5.8 nTPM
rectum: 3.8 nTPM
esophagus: 3.1 nTPM
colon: 3 nTPM
small intestine: 2.9 nTPM

Single-cell type

monocyte progenitors: 22 nCPM
enteric transient amplifying cells: 19 nCPM
gastric progenitor cells: 15 nCPM
hofbauer cells: 15 nCPM
megakaryocyte progenitors: 13 nCPM
granulosa cells: 12 nCPM

Immune cell

NK-cell: 1 nTPM
memory CD4 T-cell: 0.4 nTPM
memory CD8 T-cell: 0.3 nTPM
T-reg: 0.3 nTPM
total PBMC: 0.3 nTPM
neutrophil: 0.2 nTPM

Brain region

cerebellum: 3.9 nTPM
cerebral cortex: 2.3 nTPM
amygdala: 2.1 nTPM
white matter: 2.1 nTPM
basal ganglia: 1.8 nTPM
hypothalamus: 1.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.14
gnomAD pLI: 0
DepMap mean gene effect: -0.11
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

cell division

Cellular components

Protein domainsUniProt · Pfam · InterPro

RCS1
Regulator of chromosome segregation 1

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PIMREG in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PIMREG as an antibody target. Whether an autoantibody or antibody against PIMREG could matter depends on whether native PIMREG is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PIMREG is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PIMREG as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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