Seroatlas · Human Serome Atlas

ZNF431

Zinc finger protein 431

Also known as: KIAA1969, ZN431_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8TF32
Gene: ZNF431
Ensembl: ENSG00000196705
Chromosome: 19
Canonical length: 576 aa
Protein class: Predicted intracellular proteins, Transcription factors

OverviewNCBI Gene

This gene encodes a member of the Krueppel C2H2-type zinc-finger family of proteins. The encoded protein may negatively regulate transcription of target genes, including the hedgehog signaling pathway receptor patched 1, by interacting with histone deacetylases. Mutations in this gene may be associated with non-syndromic facial clefting in human patients. [provided by RefSeq, Jul 2016]

Canonical amino-acid sequenceUniProt

576 residues, UniProt reviewed canonical sequence.

>Q8TF32|ZNF431
     1  MDDLKYGVYP LKEASGCPGA ERNLLVYSYF EKETLTFRDV AIEFSLEEWE CLNPAQQNLY
    61  MNVMLENYKN LVFLGVAVSK QDPVTCLEQE KEPWNMKRHE MVDEPPAMCS YFTKDLWPEQ
   121  DIKDSFQQVI LRRYGKCEHE NLQLRKGSAS VDEYKVHKEG YNELNQCLTT TQSKIFPCDK
   181  YVKVFHKFLN ANRHKTRHTG KKPFKCKKCG KSFCMLLHLS QHKRIHIREN SYQCEECGKA
   241  FKWFSTLTRH KRIHTGEKPF KCEECGKAFK QSSTLTTHKI IHTGEKPYRC EECGKAFNRS
   301  SHLTTHKIIH TGEKPYKCEE CGKAFNQSST LSTHKFIHAG EKPYKCEECD KAFNRFSYLT
   361  KHKIIHTGEK SYKCEECGKG FNWSSTLTKH KRIHTGEKPY KCEVCGKAFN ESSNLTTHKM
   421  IHTGEKPYKC EECGKAFNRS PQLTAHKIIH TGEKPYKCEE CGKAFSQSSI LTTHKRIHTG
   481  EKPYKCEECG KAFNRSSNLT KHKIIHTGEK SYKCEECGKA FNQSSTLTKH RKIHTRQKPY
   541  NCEECDNTFN QSSNLIKQNN SYWRETLQMS RMWESL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF431 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.45
Highest tissue expression: 17 nTPM

Expression across tissuesHPA

Tissue

esophagus: 17 nTPM
ovary: 17 nTPM
bone marrow: 14 nTPM
thyroid gland: 11 nTPM
skin: 11 nTPM
vagina: 11 nTPM

Single-cell type

esophageal apical cells: 794 nCPM
sertoli cells: 517 nCPM
adrenal cortex cells: 347 nCPM
alveolar cells type 1: 258 nCPM
ocular epithelial cells: 180 nCPM
granulosa cells: 152 nCPM

Immune cell

NK-cell: 8.7 nTPM
memory B-cell: 8.1 nTPM
naive B-cell: 8.1 nTPM
eosinophil: 7.1 nTPM
naive CD4 T-cell: 6 nTPM
plasmacytoid DC: 5.8 nTPM

Brain region

cerebellum: 27 nTPM
white matter: 24 nTPM
pons: 21 nTPM
cerebral cortex: 20 nTPM
basal ganglia: 19 nTPM
medulla oblongata: 19 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.96
gnomAD pLI: 0.02
gnomAD missense Z: 0.19

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZNF431 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF431 as an antibody target. Whether an autoantibody or antibody against ZNF431 could matter depends on whether native ZNF431 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF431 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF431 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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