Seroatlas · Human Serome Atlas

YEATS4

YEATS domain-containing protein 4

Also known as: GAS41, NuBI-1, YAF9, YETS4_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O95619
Gene
YEATS4
Ensembl
ENSG00000127337
Chromosome
12
Canonical length
227 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Nuclear membrane

OverviewNCBI Gene

The protein encoded by this gene is found in the nucleoli. It has high sequence homology to human MLLT1, and yeast and human MLLT3 proteins. Both MLLT1 and MLLT3 proteins belong to a class of transcription factors, indicating that the encoded protein might also represent a transcription factor. This protein is thought to be required for RNA transcription. This gene has been shown to be amplified in tumors. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2014]

Canonical amino-acid sequenceUniProt

227 residues, UniProt reviewed canonical sequence.

>O95619|YEATS4
     1  MFKRMAEFGP DSGGRVKGVT IVKPIVYGNV ARYFGKKREE DGHTHQWTVY VKPYRNEDMS
    61  AYVKKIQFKL HESYGNPLRV VTKPPYEITE TGWGEFEIII KIFFIDPNER PVTLYHLLKL
   121  FQSDTNAMLG KKTVVSEFYD EMIFQDPTAM MQQLLTTSRQ LTLGAYKHET EFAELEVKTR
   181  EKLEAAKKKT SFEIAELKER LKASRETINC LKNEIRKLEE DDQAKDI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against YEATS4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.35
Highest tissue expression
43 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 43 nTPM
  • testis: 35 nTPM
  • thymus: 24 nTPM
  • lymph node: 21 nTPM
  • tonsil: 19 nTPM
  • retina: 19 nTPM

Single-cell type

  • early primary spermatocytes: 361 nCPM
  • late primary spermatocytes: 205 nCPM
  • erythrocyte progenitors: 108 nCPM
  • oocytes: 88 nCPM
  • megakaryocyte progenitors: 75 nCPM
  • differentiating spermatogonia: 74 nCPM

Immune cell

  • naive CD4 T-cell: 35 nTPM
  • T-reg: 32 nTPM
  • naive CD8 T-cell: 30 nTPM
  • memory CD4 T-cell: 30 nTPM
  • non-classical monocyte: 28 nTPM
  • eosinophil: 26 nTPM

Brain region

  • choroid plexus: 16 nTPM
  • cerebellum: 16 nTPM
  • white matter: 13 nTPM
  • spinal cord: 9.8 nTPM
  • medulla oblongata: 9.7 nTPM
  • pons: 9.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.19
gnomAD pLI
0
gnomAD missense Z
2.39
DepMap mean gene effect
-0.76
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of YEATS4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads YEATS4 as an antibody target. Whether an autoantibody or antibody against YEATS4 could matter depends on whether native YEATS4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

YEATS4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label YEATS4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/YEATS4. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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