Seroatlas · Human Serome Atlas

ARID5B

AT-rich interactive domain-containing protein 5B

Also known as: ARI5B_HUMAN, FLJ21150, MRF2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q14865
Gene: ARID5B
Ensembl: ENSG00000150347
Chromosome: 10
Canonical length: 1188 aa
Protein class: Cancer-related genes, Disease related genes, Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm,Endoplasmic reticulum,Plasma membrane,Cytosol

OverviewNCBI Gene

This gene encodes a member of the AT-rich interaction domain (ARID) family of DNA binding proteins. The encoded protein forms a histone H3K9Me2 demethylase complex with PHD finger protein 2 and regulates the transcription of target genes involved in adipogenesis and liver development. This gene also plays a role in cell growth and differentiation of B-lymphocyte progenitors, and single nucleotide polymorphisms in this gene are associated with acute lymphoblastic leukemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011]

Canonical amino-acid sequenceUniProt

1188 residues, UniProt reviewed canonical sequence.

>Q14865|ARID5B
     1  MEPNSLQWVG SPCGLHGPYI FYKAFQFHLE GKPRILSLGD FFFVRCTPKD PICIAELQLL
    61  WEERTSRQLL SSSKLYFLPE DTPQGRNSDH GEDEVIAVSE KVIVKLEDLV KWVHSDFSKW
   121  RCGFHAGPVK TEALGRNGQK EALLKYRQST LNSGLNFKDV LKEKADLGED EEETNVIVLS
   181  YPQYCRYRSM LKRIQDKPSS ILTDQFALAL GGIAVVSRNP QILYCRDTFD HPTLIENESI
   241  CDEFAPNLKG RPRKKKPCPQ RRDSFSGVKD SNNNSDGKAV AKVKCEARSA LTKPKNNHNC
   301  KKVSNEEKPK VAIGEECRAD EQAFLVALYK YMKERKTPIE RIPYLGFKQI NLWTMFQAAQ
   361  KLGGYETITA RRQWKHIYDE LGGNPGSTSA ATCTRRHYER LILPYERFIK GEEDKPLPPI
   421  KPRKQENSSQ ENENKTKVSG TKRIKHEIPK SKKEKENAPK PQDAAEVSSE QEKEQETLIS
   481  QKSIPEPLPA ADMKKKIEGY QEFSAKPLAS RVDPEKDNET DQGSNSEKVA EEAGEKGPTP
   541  PLPSAPLAPE KDSALVPGAS KQPLTSPSAL VDSKQESKLC CFTESPESEP QEASFPSFPT
   601  TQPPLANQNE TEDDKLPAMA DYIANCTVKV DQLGSDDIHN ALKQTPKVLV VQSFDMFKDK
   661  DLTGPMNENH GLNYTPLLYS RGNPGIMSPL AKKKLLSQVS GASLSSSYPY GSPPPLISKK
   721  KLIARDDLCS SLSQTHHGQS TDHMAVSRPS VIQHVQSFRS KPSEERKTIN DIFKHEKLSR
   781  SDPHRCSFSK HHLNPLADSY VLKQEIQEGK DKLLEKRALP HSHMPSFLAD FYSSPHLHSL
   841  YRHTEHHLHN EQTSKYPSRD MYRESENSSF PSHRHQEKLH VNYLTSLHLQ DKKSAAAEAP
   901  TDDQPTDLSL PKNPHKPTGK VLGLAHSTTG PQESKGISQF QVLGSQSRDC HPKACRVSPM
   961  TMSGPKKYPE SLSRSGKPHH VRLENFRKME GMVHPILHRK MSPQNIGAAR PIKRSLEDLD
  1021  LVIAGKKARA VSPLDPSKEV SGKEKASEQE SEGSKAAHGG HSGGGSEGHK LPLSSPIFPG
  1081  LYSGSLCNSG LNSRLPAGYS HSLQYLKNQT VLSPLMQPLA FHSLVMQRGI FTSPTNSQQL
  1141  YRHLAAATPV GSSYGDLLHN SIYPLAAINP QAAFPSSQLS SVHPSTKL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ARID5B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.59
Highest tissue expression: 84 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 84 nTPM
adipose tissue: 47 nTPM
blood vessel: 41 nTPM
smooth muscle: 40 nTPM
gallbladder: 37 nTPM
endometrium: 37 nTPM

Single-cell type

syncytiotrophoblasts: 1,516 nCPM
endometrial glandular cells: 1,191 nCPM
basal keratinocytes: 1,081 nCPM
b-cells: 979 nCPM
smooth muscle cells: 970 nCPM
thymic myoid cells: 838 nCPM

Immune cell

naive B-cell: 41 nTPM
memory B-cell: 38 nTPM
T-reg: 31 nTPM
memory CD4 T-cell: 20 nTPM
gdT-cell: 13 nTPM
naive CD4 T-cell: 13 nTPM

Brain region

choroid plexus: 72 nTPM
cerebral cortex: 55 nTPM
pons: 53 nTPM
thalamus: 49 nTPM
white matter: 47 nTPM
medulla oblongata: 45 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about ARID5B.

Disease | AllUniProt

Conditions ARID5B is implicated in, by any mechanism.

Leukemia, acute lymphoblastic (ALL) MIM:613065

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.11
gnomAD pLI: 1
gnomAD missense Z: 2.6
DepMap mean gene effect: -0.01
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

ARID DNA-binding domain
ARID DNA-binding domain superfamily
AT-rich Interactive Domain/SWI1 Chromatin Remodeling
ARID/BRIGHT DNA binding domain
AT-rich interactive domain-containing protein 5B, ARID/BRIGHT DNA binding domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ARID5B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ARID5B as an antibody target. Whether an autoantibody or antibody against ARID5B could matter depends on whether native ARID5B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ARID5B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ARID5B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...