ANP32E
Acidic leucine-rich nuclear phosphoprotein 32 family member E
Also known as: AN32E_HUMAN, LANP-L, LANPL, MGC5350
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q9BTT0
- Gene
- ANP32E
- Ensembl
- ENSG00000143401
- Chromosome
- 1
- Canonical length
- 268 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Nucleoplasm,Centrosome,Cytosol
OverviewNCBI Gene
Enables histone binding activity; histone chaperone activity; and protein folding chaperone. Predicted to be involved in regulation of apoptotic process. Located in nucleus. Part of Swr1 complex. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
268 residues, UniProt reviewed canonical sequence.
>Q9BTT0|ANP32E
1 MEMKKKINLE LRNRSPEEVT ELVLDNCLCV NGEIEGLNDT FKELEFLSMA NVELSSLARL
61 PSLNKLRKLE LSDNIISGGL EVLAEKCPNL TYLNLSGNKI KDLSTVEALQ NLKNLKSLDL
121 FNCEITNLED YRESIFELLQ QITYLDGFDQ EDNEAPDSEE EDDEDGDEDD EEEEENEAGP
181 PEGYEEEEEE EEEEDEDEDE DEDEAGSELG EGEEEVGLSY LMKEEIQDEE DDDDYVEEGE
241 EEEEEEEGGL RGEKRKRDAE DDGEEEDDLocalizationUniProt · AlphaFold · HPA
Whether an antibody against ANP32E can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.46
- Highest tissue expression
- 91 nTPM
Expression across tissuesHPA
Tissue
- retina: 91 nTPM
- thymus: 82 nTPM
- bone marrow: 71 nTPM
- lymph node: 66 nTPM
- cerebellum: 59 nTPM
- tonsil: 58 nTPM
Single-cell type
- monocyte progenitors: 397 nCPM
- neutrophil progenitors: 220 nCPM
- megakaryocyte progenitors: 202 nCPM
- erythrocyte progenitors: 191 nCPM
- extravillous trophoblasts: 159 nCPM
- rod photoreceptor cells: 139 nCPM
Immune cell
- basophil: 57 nTPM
- T-reg: 56 nTPM
- memory B-cell: 55 nTPM
- MAIT T-cell: 53 nTPM
- memory CD4 T-cell: 47 nTPM
- naive CD8 T-cell: 41 nTPM
Brain region
- cerebellum: 90 nTPM
- medulla oblongata: 68 nTPM
- midbrain: 64 nTPM
- thalamus: 63 nTPM
- hypothalamus: 61 nTPM
- spinal cord: 60 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.42
- gnomAD pLI
- 0.84
- gnomAD missense Z
- 2.05
- DepMap mean gene effect
- -0.26
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 11% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of ANP32E in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads ANP32E as an antibody target. Whether an autoantibody or antibody against ANP32E could matter depends on whether native ANP32E is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
ANP32E is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label ANP32E as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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