Seroatlas · Human Serome Atlas

PRUNE1

Exopolyphosphatase PRUNE1

Also known as: DRES-17, H-PRUNE, HTCD37, PRUN1_HUMAN, PRUNE

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q86TP1
Gene
PRUNE1
Ensembl
ENSG00000143363
Chromosome
1
Canonical length
453 aa
Protein class
Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins
Subcellular location
Cytosol
Quaternary structure
Homodimer

OverviewNCBI Gene

This gene encodes a member of the DHH protein superfamily of phosphoesterases. This protein has been found to function as both a nucleotide phosphodiesterase and an exopolyphosphatase. This protein is believed to stimulate cancer progression and metastases through the induction of cell motility. A pseuodgene has been identified on chromosome 13. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]

Canonical amino-acid sequenceUniProt

453 residues, UniProt reviewed canonical sequence.

>Q86TP1|PRUNE1
     1  MEDYLQGCRA ALQESRPLHV VLGNEACDLD STVSALALAF YLAKTTEAEE VFVPVLNIKR
    61  SELPLRGDIV FFLQKVHIPE SILIFRDEID LHALYQAGQL TLILVDHHIL SKSDTALEEA
   121  VAEVLDHRPI EPKHCPPCHV SVELVGSCAT LVTERILQGA PEILDRQTAA LLHGTIILDC
   181  VNMDLKIGKA TPKDSKYVEK LEALFPDLPK RNDIFDSLQK AKFDVSGLTT EQMLRKDQKT
   241  IYRQGVKVAI SAIYMDLEAF LQRSNLLADL HAFCQAHSYD VLVAMTIFFN THNEPVRQLA
   301  IFCPHVALQT TICEVLERSH SPPLKLTPAS STHPNLHAYL QGNTQVSRKK LLPLLQEALS
   361  AYFDSMKIPS GQPETADVSR EQVDKELDRA SNSLISGLSQ DEEDPPLPPT PMNSLVDECP
   421  LDQGLPKLSA EAVFEKCSQI SLSQSTTASL SKK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PRUNE1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.31
Highest tissue expression
31 nTPM

Expression across tissuesHPA

Tissue

  • heart muscle: 31 nTPM
  • thyroid gland: 31 nTPM
  • skeletal muscle: 28 nTPM
  • tongue: 20 nTPM
  • parathyroid gland: 20 nTPM
  • testis: 18 nTPM

Single-cell type

  • platelets: 178 nCPM
  • late spermatids: 99 nCPM
  • early spermatids: 82 nCPM
  • megakaryocytes: 74 nCPM
  • cone photoreceptor cells: 50 nCPM
  • renal collecting duct intercalated cells: 37 nCPM

Immune cell

  • total PBMC: 22 nTPM
  • naive CD4 T-cell: 22 nTPM
  • MAIT T-cell: 20 nTPM
  • basophil: 19 nTPM
  • NK-cell: 19 nTPM
  • memory CD8 T-cell: 19 nTPM

Brain region

  • cerebellum: 23 nTPM
  • white matter: 17 nTPM
  • hypothalamus: 17 nTPM
  • cerebral cortex: 16 nTPM
  • choroid plexus: 16 nTPM
  • midbrain: 16 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about PRUNE1.

Disease | AllUniProt

Conditions PRUNE1 is implicated in, by any mechanism.

  • Neurodevelopmental disorder with microcephaly, hypotonia, and variable brain anomalies (NMIHBA) MIM:617481

Disease | GeneticClinVar

27 pathogenic / likely-pathogenic of 148 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.66
gnomAD pLI
0.01
DepMap mean gene effect
-0.33
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 19% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PRUNE1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PRUNE1 as an antibody target. Whether an autoantibody or antibody against PRUNE1 could matter depends on whether native PRUNE1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PRUNE1 is annotated at the cell surface, where native PRUNE1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label PRUNE1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PRUNE1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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