Seroatlas · Human Serome Atlas

TNFRSF10B

Tumor necrosis factor receptor superfamily member 10B

Also known as: CD262, DR5, KILLER, TR10B_HUMAN, TRAIL-R2, TRAILR2, TRICK2A, TRICKB

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O14763
Gene
TNFRSF10B
Ensembl
ENSG00000120889
Chromosome
8
Canonical length
440 aa
Protein class
Cancer-related genes, CD markers, Disease related genes, Human disease related genes, Plasma proteins, Predicted membrane proteins
Quaternary structure
Homotrimer

OverviewNCBI Gene

The protein encoded by this gene is a member of the TNF-receptor superfamily, and contains an intracellular death domain. This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces an apoptosis signal. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. Two transcript variants encoding different isoforms and one non-coding transcript have been found for this gene. [provided by RefSeq, Mar 2009]

Canonical amino-acid sequenceUniProt

440 residues, UniProt reviewed canonical sequence.

>O14763|TNFRSF10B
     1  MEQRGQNAPA ASGARKRHGP GPREARGARP GPRVPKTLVL VVAAVLLLVS AESALITQQD
    61  LAPQQRAAPQ QKRSSPSEGL CPPGHHISED GRDCISCKYG QDYSTHWNDL LFCLRCTRCD
   121  SGEVELSPCT TTRNTVCQCE EGTFREEDSP EMCRKCRTGC PRGMVKVGDC TPWSDIECVH
   181  KESGTKHSGE VPAVEETVTS SPGTPASPCS LSGIIIGVTV AAVVLIVAVF VCKSLLWKKV
   241  LPYLKGICSG GGGDPERVDR SSQRPGAEDN VLNEIVSILQ PTQVPEQEME VQEPAEPTGV
   301  NMLSPGESEH LLEPAEAERS QRRRLLVPAN EGDPTETLRQ CFDDFADLVP FDSWEPLMRK
   361  LGLMDNEIKV AKAEAAGHRD TLYTMLIKWV NKTGRDASVH TLLDALETLG ERLAKQKIED
   421  HLLSSGKFMY LEGNADSAMS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TNFRSF10B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.51
Highest tissue expression
33 nTPM

Expression across tissuesHPA

Tissue

  • liver: 33 nTPM
  • urinary bladder: 29 nTPM
  • small intestine: 25 nTPM
  • lung: 25 nTPM
  • pancreas: 24 nTPM
  • adrenal gland: 24 nTPM

Single-cell type

  • urothelial cells: 395 nCPM
  • enterocytes: 371 nCPM
  • endometrial glandular cells: 312 nCPM
  • prostatic hillock cells: 261 nCPM
  • salivary basal cells: 256 nCPM
  • respiratory basal cells: 253 nCPM

Immune cell

  • classical monocyte: 18 nTPM
  • non-classical monocyte: 18 nTPM
  • myeloid DC: 16 nTPM
  • intermediate monocyte: 13 nTPM
  • total PBMC: 7.7 nTPM
  • naive CD4 T-cell: 4.7 nTPM

Brain region

  • choroid plexus: 38 nTPM
  • thalamus: 11 nTPM
  • spinal cord: 8.1 nTPM
  • midbrain: 7.9 nTPM
  • hippocampal formation: 7.8 nTPM
  • medulla oblongata: 7.8 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about TNFRSF10B.

Disease | AllUniProt

Conditions TNFRSF10B is implicated in, by any mechanism.

  • Squamous cell carcinoma of the head and neck (HNSCC) MIM:275355

Disease | GeneticClinVar

2 pathogenic / likely-pathogenic of 96 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.85
gnomAD pLI
0
gnomAD missense Z
-0.67
DepMap mean gene effect
0.18
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TNFRSF10B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TNFRSF10B as an antibody target. Whether an autoantibody or antibody against TNFRSF10B could matter depends on whether native TNFRSF10B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TNFRSF10B is annotated at the cell surface, where native TNFRSF10B is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label TNFRSF10B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TNFRSF10B. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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