Seroatlas · Human Serome Atlas

PHF13

PHD finger protein 13

Also known as: MGC43399, PHF13_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q86YI8
Gene: PHF13
Ensembl: ENSG00000116273
Chromosome: 1
Canonical length: 300 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Enables chromatin binding activity; chromatin-protein adaptor activity; and methylated histone binding activity. Involved in mitotic chromosome condensation and regulation of DNA repair. Located in nucleus. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

300 residues, UniProt reviewed canonical sequence.

>Q86YI8|PHF13
     1  MDSDSCAAAF HPEEYSPSCK RRRTVEDFNK FCTFVLAYAG YIPYPKEELP LRSSPSPANS
    61  TAGTIDSDGW DAGFSDIASS VPLPVSDRCF SHLQPTLLQR AKPSNFLLDR KKTDKLKKKK
   121  KRKRRDSDAP GKEGYRGGLL KLEAADPYVE TPTSPTLQDI PQAPSDPCSG WDSDTPSSGS
   181  CATVSPDQVK EIKTEGKRTI VRQGKQVVFR DEDSTGNDED IMVDSDDDSW DLVTCFCMKP
   241  FAGRPMIECN ECHTWIHLSC AKIRKSNVPE VFVCQKCRDS KFDIRRSNRS RTGSRKLFLD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PHF13 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.63
Highest tissue expression: 33 nTPM

Expression across tissuesHPA

Tissue

testis: 33 nTPM
cervix: 19 nTPM
blood vessel: 19 nTPM
colon: 16 nTPM
endometrium: 16 nTPM
esophagus: 15 nTPM

Single-cell type

undifferentiated spermatogonia: 53 nCPM
esophageal apical cells: 45 nCPM
differentiating spermatogonia: 40 nCPM
syncytiotrophoblasts: 37 nCPM
ocular epithelial cells: 36 nCPM
suprabasal keratinocytes: 35 nCPM

Immune cell

eosinophil: 4.6 nTPM
neutrophil: 4.1 nTPM
MAIT T-cell: 3.6 nTPM
memory CD4 T-cell: 3 nTPM
NK-cell: 2.8 nTPM
T-reg: 2.5 nTPM

Brain region

hypothalamus: 14 nTPM
white matter: 13 nTPM
medulla oblongata: 12 nTPM
cerebral cortex: 12 nTPM
midbrain: 11 nTPM
hippocampal formation: 11 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.25
gnomAD pLI: 0.98
gnomAD missense Z: 1.76
DepMap mean gene effect: -0.07
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PHF13 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PHF13 as an antibody target. Whether an autoantibody or antibody against PHF13 could matter depends on whether native PHF13 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PHF13 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PHF13 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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