Seroatlas · Human Serome Atlas

JPT1

Jupiter microtubule associated homolog 1

Also known as: ARM2, HN1, HN1A, JUPI1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9UK76
Gene: JPT1
Ensembl: ENSG00000189159
Chromosome: 17
Canonical length: 154 aa
Protein class: Plasma proteins, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Microtubules,Cytokinetic bridge,Cytosol

OverviewNCBI Gene

Located in several cellular components, including intercellular bridge; microtubule cytoskeleton; and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

154 residues, UniProt reviewed canonical sequence.

>Q9UK76|JPT1
     1  MTTTTTFKGV DPNSRNSSRV LRPPGGGSNF SLGFDEPTEQ PVRKNKMASN IFGTPEENQA
    61  SWAKSAGAKS SGGREDLESS GLQRRNSSEA SSGDFLDLKG EGDIHENVDT DLPGSLGQSE
   121  EKPVPAAPVP SPVAPAPVPS RRNPPGGKSS LVLG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against JPT1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.72
Highest tissue expression: 395 nTPM

Expression across tissuesHPA

Tissue

testis: 395 nTPM
esophagus: 213 nTPM
small intestine: 133 nTPM
colon: 131 nTPM
stomach: 126 nTPM
cerebellum: 113 nTPM

Single-cell type

extravillous trophoblasts: 2,152 nCPM
late primary spermatocytes: 2,044 nCPM
late spermatids: 1,774 nCPM
esophageal apical cells: 1,438 nCPM
early spermatids: 1,315 nCPM
esophageal suprabasal cells: 1,070 nCPM

Immune cell

neutrophil: 774 nTPM
eosinophil: 375 nTPM
basophil: 244 nTPM
non-classical monocyte: 208 nTPM
T-reg: 204 nTPM
intermediate monocyte: 189 nTPM

Brain region

hypothalamus: 72 nTPM
pons: 62 nTPM
cerebellum: 60 nTPM
cerebral cortex: 50 nTPM
basal ganglia: 49 nTPM
midbrain: 47 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.28
gnomAD pLI: 0
DepMap mean gene effect: -0.17
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of JPT1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads JPT1 as an antibody target. Whether an autoantibody or antibody against JPT1 could matter depends on whether native JPT1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

JPT1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label JPT1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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