Seroatlas · Human Serome Atlas

TNFRSF10A

Tumor necrosis factor receptor superfamily member 10A

Also known as: Apo2, CD261, DR4, TR10A_HUMAN, TRAILR-1, TRAILR1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O00220
Gene
TNFRSF10A
Ensembl
ENSG00000104689
Chromosome
8
Canonical length
468 aa
Protein class
Cancer-related genes, CD markers, Predicted membrane proteins
Quaternary structure
Homotrimer

OverviewNCBI Gene

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL), and thus transduces cell death signal and induces cell apoptosis. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

468 residues, UniProt reviewed canonical sequence.

>O00220|TNFRSF10A
     1  MAPPPARVHL GAFLAVTPNP GSAASGTEAA AATPSKVWGS SAGRIEPRGG GRGALPTSMG
    61  QHGPSARARA GRAPGPRPAR EASPRLRVHK TFKFVVVGVL LQVVPSSAAT IKLHDQSIGT
   121  QQWEHSPLGE LCPPGSHRSE HPGACNRCTE GVGYTNASNN LFACLPCTAC KSDEEERSPC
   181  TTTRNTACQC KPGTFRNDNS AEMCRKCSRG CPRGMVKVKD CTPWSDIECV HKESGNGHNI
   241  WVILVVTLVV PLLLVAVLIV CCCIGSGCGG DPKCMDRVCF WRLGLLRGPG AEDNAHNEIL
   301  SNADSLSTFV SEQQMESQEP ADLTGVTVQS PGEAQCLLGP AEAEGSQRRR LLVPANGADP
   361  TETLMLFFDK FANIVPFDSW DQLMRQLDLT KNEIDVVRAG TAGPGDALYA MLMKWVNKTG
   421  RNASIHTLLD ALERMEERHA REKIQDLLVD SGKFIYLEDG TGSAVSLE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TNFRSF10A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.54
Highest tissue expression
13 nTPM

Expression across tissuesHPA

Tissue

  • tonsil: 13 nTPM
  • lymph node: 13 nTPM
  • urinary bladder: 10 nTPM
  • appendix: 9.3 nTPM
  • bone marrow: 8.8 nTPM
  • esophagus: 8.1 nTPM

Single-cell type

  • suprabasal keratinocytes: 63 nCPM
  • ocular epithelial cells: 61 nCPM
  • basal keratinocytes: 59 nCPM
  • vascular endothelial cells: 53 nCPM
  • endometrial luminal cells: 51 nCPM
  • b-cells: 51 nCPM

Immune cell

  • T-reg: 21 nTPM
  • naive B-cell: 19 nTPM
  • memory CD4 T-cell: 16 nTPM
  • naive CD4 T-cell: 16 nTPM
  • memory B-cell: 15 nTPM
  • MAIT T-cell: 14 nTPM

Brain region

  • thalamus: 6.4 nTPM
  • medulla oblongata: 6.1 nTPM
  • pons: 5.8 nTPM
  • midbrain: 5.1 nTPM
  • spinal cord: 5.1 nTPM
  • cerebral cortex: 4.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.56
gnomAD pLI
0
gnomAD missense Z
-0.65
DepMap mean gene effect
0.01
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TNFRSF10A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TNFRSF10A as an antibody target. Whether an autoantibody or antibody against TNFRSF10A could matter depends on whether native TNFRSF10A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TNFRSF10A is annotated at the cell surface, where native TNFRSF10A is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label TNFRSF10A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TNFRSF10A. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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