GSKIP

Protein identityUniProt · HPA

UniProt accession

Q9P0R6

Gene

GSKIP

Ensembl

ENSG00000100744

Chromosome

14

Canonical length

139 aa

Protein class

Predicted intracellular proteins

Subcellular location

Nucleoli,Golgi apparatus,Vesicles

OverviewNCBI Gene

This gene encodes a protein that is involved as a negative regulator of GSK3-beta in the Wnt signaling pathway. The encoded protein may play a role in the retinoic acid signaling pathway by regulating the functional interactions between GSK3-beta, beta-catenin and cyclin D1, and it regulates the beta-catenin/N-cadherin pool. The encoded protein contains a GSK3-beta interacting domain (GID) in its C-terminus, which is similar to the GID of Axin. The protein also contains an evolutionarily conserved RII-binding domain, which facilitates binding with protein kinase-A and GSK3-beta, enabling its role as an A-kinase anchoring protein. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Dec 2012]

Canonical amino-acid sequenceUniProt

139 residues, UniProt reviewed canonical sequence.

>Q9P0R6|GSKIP
     1  METDCNPMEL SSMSGFEEGS ELNGFEGTDM KDMRLEAEAV VNDVLFAVNN MFVSKSLRCA
    61  DDVAYINVET KERNRYCLEL TEAGLKVVGY AFDQVDDHLQ TPYHETVYSL LDTLSPAYRE
   121  AFGNALLQRL EALKRDGQS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GSKIP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.41

Highest tissue expression

63 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.97

gnomAD pLI

0.38

gnomAD missense Z

0.98

DepMap mean gene effect

0.13

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• intrinsic apoptotic signaling pathway in response to oxidative stress
• negative regulation of protein kinase activity
• positive regulation of canonical Wnt signaling pathway
• regulation of Wnt signaling pathway

Molecular functions

• kinase regulator activity
• protein kinase A binding
• protein kinase A regulatory subunit binding
• protein kinase binding
• protein kinase inhibitor activity

Cellular components

• cytoplasm
• nucleus

Protein domainsUniProt · Pfam · InterPro

• GSKIP domain superfamily
• GSKIP domain
• GSK3B-interacting protein
• GSKIP domain

KeywordsUniProt

• Cytoplasm
• Nucleus

InteractionsUniProt · HPA

Protein binding partners of GSKIP in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• GSK3B
• GSK3A