Seroatlas · Human Serome Atlas

SGK3

Serine/threonine-protein kinase Sgk3

Also known as: SGK2, SGK3_HUMAN, SGKL

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96BR1
Gene: SGK3
Ensembl: ENSG00000104205
Chromosome: 8
Canonical length: 496 aa
Protein class: Enzymes, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Vesicles

OverviewNCBI Gene

This gene is a member of the Ser/Thr protein kinase family and encodes a phosphoprotein with a PX (phox homology) domain. The protein phosphorylates several target proteins and has a role in neutral amino acid transport and activation of potassium and chloride channels. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

496 residues, UniProt reviewed canonical sequence.

>Q96BR1|SGK3
     1  MQRDHTMDYK ESCPSVSIPS SDEHREKKKR FTVYKVLVSV GRSEWFVFRR YAEFDKLYNT
    61  LKKQFPAMAL KIPAKRIFGD NFDPDFIKQR RAGLNEFIQN LVRYPELYNH PDVRAFLQMD
   121  SPKHQSDPSE DEDERSSQKL HSTSQNINLG PSGNPHAKPT DFDFLKVIGK GSFGKVLLAK
   181  RKLDGKFYAV KVLQKKIVLN RKEQKHIMAE RNVLLKNVKH PFLVGLHYSF QTTEKLYFVL
   241  DFVNGGELFF HLQRERSFPE HRARFYAAEI ASALGYLHSI KIVYRDLKPE NILLDSVGHV
   301  VLTDFGLCKE GIAISDTTTT FCGTPEYLAP EVIRKQPYDN TVDWWCLGAV LYEMLYGLPP
   361  FYCRDVAEMY DNILHKPLSL RPGVSLTAWS ILEELLEKDR QNRLGAKEDF LEIQNHPFFE
   421  SLSWADLVQK KIPPPFNPNV AGPDDIRNFD TAFTEETVPY SVCVSSDYSI VNASVLEADD
   481  AFVGFSYAPP SEDLFL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SGK3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.29
Highest tissue expression: 27 nTPM

Expression across tissuesHPA

Tissue

parathyroid gland: 27 nTPM
spinal cord: 24 nTPM
breast: 23 nTPM
choroid plexus: 22 nTPM
thyroid gland: 16 nTPM
pancreas: 15 nTPM

Single-cell type

choroid plexus epithelial cells: 728 nCPM
oligodendrocytes: 459 nCPM
retinal pigment epithelial cells: 294 nCPM
astrocytes: 252 nCPM
microglia: 235 nCPM
proximal tubule cells: 207 nCPM

Immune cell

basophil: 21 nTPM
classical monocyte: 15 nTPM
MAIT T-cell: 14 nTPM
myeloid DC: 14 nTPM
intermediate monocyte: 9.9 nTPM
total PBMC: 9 nTPM

Brain region

white matter: 97 nTPM
choroid plexus: 74 nTPM
medulla oblongata: 60 nTPM
basal ganglia: 51 nTPM
pons: 49 nTPM
midbrain: 43 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.76
gnomAD pLI: 0
gnomAD missense Z: 1.65
DepMap mean gene effect: 0.15
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Protein kinase domain
AGC-kinase, C-terminal
Phox homology
Serine/threonine-protein kinase, active site
Protein kinase-like domain superfamily
Protein kinase, ATP binding site
Protein kinase, C-terminal
PX domain superfamily
Protein kinase domain
Protein kinase C terminal domain
PX domain
Serine/threonine-protein kinase Sgk3, catalytic domain
CISK, PX domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SGK3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SGK3 as an antibody target. Whether an autoantibody or antibody against SGK3 could matter depends on whether native SGK3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SGK3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SGK3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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