Seroatlas · Human Serome Atlas

ZBED3

Zinc finger BED domain-containing protein 3

Also known as: MGC15435, ZBED3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96IU2
Gene: ZBED3
Ensembl: ENSG00000132846
Chromosome: 5
Canonical length: 234 aa
Protein class: Predicted intracellular proteins, Predicted secreted proteins, Transcription factors
Subcellular location: Nucleoplasm,Plasma membrane
Secretome location: Secreted to blood

OverviewNCBI Gene

This gene belongs to a class of genes that arose through hAT DNA transposition and that encode regulatory proteins. This gene is upregulated in lung cancer tissues, where the encoded protein causes an accumulation of beta-catenin and enhanced lung cancer cell invasion. In addition, the encoded protein can be secreted and be involved in resistance to insulin. [provided by RefSeq, Jul 2016]

Canonical amino-acid sequenceUniProt

234 residues, UniProt reviewed canonical sequence.

>Q96IU2|ZBED3
     1  MRSGEPACTM DQARGLDDAA ARGGQCPGLG PAPTPTPPGR LGAPYSEAWG YFHLAPGRPG
    61  HPSGHWATCR LCGEQVGRGP GFHAGTSALW RHLRSAHRRE LESSGAGSSP PAAPCPPPPG
   121  PAAAPEGDWA RLLEQMGALA VRGSRREREL ERRELAVEQG ERALERRRRA LQEEERAAAQ
   181  ARRELQAERE ALQARLRDVS RREGALGWAP AAPPPLKDDP EGDRDGCVIT KVLL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZBED3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.55
Highest tissue expression: 11 nTPM

Expression across tissuesHPA

Tissue

thyroid gland: 11 nTPM
endometrium: 10 nTPM
liver: 10 nTPM
adipose tissue: 9.7 nTPM
kidney: 9.3 nTPM
breast: 8.8 nTPM

Single-cell type

retinal pigment epithelial cells: 43 nCPM
hepatocytes: 40 nCPM
hematopoietic stem cells: 40 nCPM
adipocytes: 39 nCPM
cardiomyocytes: 38 nCPM
breast lactating cells: 38 nCPM

Immune cell

plasmacytoid DC: 0.2 nTPM
classical monocyte: 0.1 nTPM
myeloid DC: 0.1 nTPM
naive CD4 T-cell: 0.1 nTPM
naive CD8 T-cell: 0.1 nTPM
basophil: 0 nTPM

Brain region

white matter: 33 nTPM
medulla oblongata: 32 nTPM
basal ganglia: 27 nTPM
thalamus: 26 nTPM
midbrain: 23 nTPM
pons: 21 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.91
gnomAD pLI: 0.08
gnomAD missense Z: 0.91
DepMap mean gene effect: 0.01
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZBED3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZBED3 as an antibody target. Whether an autoantibody or antibody against ZBED3 could matter depends on whether native ZBED3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZBED3 is annotated as secreted, so native ZBED3 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label ZBED3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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