Seroatlas · Human Serome Atlas

DYNLT2B

Dynein light chain Tctex-type protein 2B

Also known as: DYT2B_HUMAN, MGC33212, TCTEX1D2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8WW35
Gene
DYNLT2B
Ensembl
ENSG00000213123
Chromosome
3
Canonical length
142 aa
Protein class
Disease related genes, Human disease related genes, Predicted intracellular proteins
Subcellular location
Microtubules,Mitotic spindle,Primary cilium,Basal body,Cytosol

OverviewNCBI Gene

Dyneins are a group of microtubule-activated ATPases that function as molecular motors. They are divided into two subgroups of axonemal and cytoplasmic dyneins. The cytoplasmic dyneins function in intracellular motility, including retrograde axonal transport, protein sorting, organelle movement, and spindle dynamics. Molecules of conventional cytoplasmic dynein are comprised of 2 heavy chain polypeptides and a number of intermediate and light chains. This gene encodes a subunit of the human cytoplasmic dynein-2 complex. Mutations in this gene are associated with short-rib thoracic dysplasia 17 with or without polydactyly. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2017]

Canonical amino-acid sequenceUniProt

142 residues, UniProt reviewed canonical sequence.

>Q8WW35|DYNLT2B
     1  MATSIGVSFS VGDGVPEAEK NAGEPENTYI LRPVFQQRFR PSVVKDCIHA VLKEELANAE
    61  YSPEEMPQLT KHLSENIKDK LKEMGFDRYK MVVQVVIGEQ RGEGVFMASR CFWDADTDNY
   121  THDVFMNDSL FCVVAAFGCF YY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DYNLT2B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.41
Highest tissue expression
34 nTPM

Expression across tissuesHPA

Tissue

  • fallopian tube: 34 nTPM
  • testis: 30 nTPM
  • basal ganglia: 29 nTPM
  • amygdala: 29 nTPM
  • cerebral cortex: 29 nTPM
  • hypothalamus: 27 nTPM

Single-cell type

  • fallopian tube ciliated cells: 424 nCPM
  • epididymal efferent duct ciliated cells: 361 nCPM
  • early primary spermatocytes: 347 nCPM
  • respiratory ciliated cells: 339 nCPM
  • late primary spermatocytes: 242 nCPM
  • endometrial ciliated cells: 202 nCPM

Immune cell

  • T-reg: 25 nTPM
  • memory B-cell: 22 nTPM
  • plasmacytoid DC: 16 nTPM
  • memory CD4 T-cell: 14 nTPM
  • naive B-cell: 14 nTPM
  • gdT-cell: 12 nTPM

Brain region

  • medulla oblongata: 14 nTPM
  • midbrain: 14 nTPM
  • hypothalamus: 12 nTPM
  • spinal cord: 10 nTPM
  • basal ganglia: 9.9 nTPM
  • cerebral cortex: 9.3 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about DYNLT2B.

Disease | AllUniProt

Conditions DYNLT2B is implicated in, by any mechanism.

  • Short-rib thoracic dysplasia 17 with or without polydactyly (SRTD17) MIM:617405

Disease | GeneticClinVar

8 pathogenic / likely-pathogenic of 79 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.49
gnomAD pLI
0
DepMap mean gene effect
-0.03
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of DYNLT2B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DYNLT2B as an antibody target. Whether an autoantibody or antibody against DYNLT2B could matter depends on whether native DYNLT2B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DYNLT2B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DYNLT2B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/DYNLT2B. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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